Persistent alterations of cortical hemodynamic response in asymptomatic concussed patients.

Q3 Medicine Concussion Pub Date : 2020-10-28 DOI:10.2217/cnc-2020-0014

Allyssa K Memmini, Xin Sun, Xiaosu Hu, Jessica Kim, Noelle K Herzog, Mohammed N Islam, Daniel H Weissman, Alexander J Rogers, Ioulia Kovelman, Steven P Broglio

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Abstract

Aim: The underlying neurophysiological effects of concussion often result in attenuated cognitive and cortical function. To understand the relation between cognition and brain injury, we investigated the effects of concussion on attentional networks using functional near-infrared spectroscopy (fNIRS).

Materials & methods: Healthy controls and concussed patients, tested within 72 h from injury (T1) and after symptoms resolved (T2) completed a computerized attention task during fNIRS imaging.

Results: T1 patients exhibited slower reaction times and reduced brain activation pattern relative to healthy controls. Interestingly, the cortical oxygenation hemoglobin response at T2 was greater relative to T1 and healthy controls, while reaction time was normative.

Conclusion: The exploratory findings of this study suggest once asymptomatic, a compensatory hemodynamic response may support the restoration of reaction time despite ongoing physiological recovery.

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无症状脑震荡患者大脑皮层血流动力学反应的持续改变。

目的：脑震荡的潜在神经生理效应通常会导致认知和皮层功能减弱。为了了解认知与脑损伤之间的关系，我们利用功能性近红外光谱（fNIRS）研究了脑震荡对注意力网络的影响。材料与方法：健康对照组和脑震荡患者在受伤后 72 小时内（T1）和症状缓解后（T2）接受测试，在进行 fNIRS 成像时完成一项计算机化注意力任务：结果：与健康对照组相比，T1 患者的反应时间更慢，大脑激活模式更弱。有趣的是，与 T1 和健康对照组相比，T2 患者的皮层氧合血红蛋白反应更强，而反应时间则正常：本研究的探索性发现表明，一旦无症状，尽管生理机能正在恢复，但补偿性血液动力学反应可能会支持反应时间的恢复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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