In vitro interaction between glabridin and voriconazole against Aspergillus fumigatus isolates

IF 1.5 4区生物学 Q4 MYCOLOGY Revista Iberoamericana De Micologia Pub Date : 2021-07-01 DOI:10.1016/j.riam.2020.12.005

Mojtaba Nabili , Narges Aslani , Tahereh Shokohi , Mohammad Taghi Hedayati , Fozieh Hassanmoghadam , Maryam Moazeni

{"title":"In vitro interaction between glabridin and voriconazole against Aspergillus fumigatus isolates","authors":"Mojtaba Nabili , Narges Aslani , Tahereh Shokohi , Mohammad Taghi Hedayati , Fozieh Hassanmoghadam , Maryam Moazeni","doi":"10.1016/j.riam.2020.12.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Voriconazole (VRC) is widely recommended as the first-line therapy for invasive aspergillosis. However, surveillance studies have demonstrated that there is an increase in the frequency of azole resistance among <em>Aspergillus fumigates</em> isolates. In recent years, more studies on effective synergisms between natural agents and antifungal drugs have been published.</p></div><div><h3>Aims</h3><p>To evaluate the synergistic antifungal effect of glabridin (Gla) and VRC against <em>A. fumigatus</em> isolates.</p></div><div><h3>Methods</h3><p>Potential interactions between Gla and VRC were studied by using a microdilution checkerboard method based on the CLSI reference technique. To assess the interaction of drugs the fractional inhibitory concentration index (FICI) was calculated based on the Loewe Additivity model.</p></div><div><h3>Results</h3><p>The minimum inhibitory concentrations (MIC) obtained with Gla alone were relatively high (MIC<sub>50</sub> 16μg/ml). However, our results showed synergistic interaction between Gla and VRC against <em>A. fumigatus</em><span> strains, with FICI range values between 0.15 and 0.5.</span></p></div><div><h3>Conclusions</h3><p>Synergistic activity of Gla and VRC against both VRC-sensitive and -resistant <em>A. fumigatus</em> isolates may lead to design new antifungal agents, especially for inhibiting those azole-resistant strains.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"38 3","pages":"Pages 145-147"},"PeriodicalIF":1.5000,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2020.12.005","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Iberoamericana De Micologia","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1130140621000127","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MYCOLOGY","Score":null,"Total":0}

引用次数: 2

Abstract

Background

Voriconazole (VRC) is widely recommended as the first-line therapy for invasive aspergillosis. However, surveillance studies have demonstrated that there is an increase in the frequency of azole resistance among Aspergillus fumigates isolates. In recent years, more studies on effective synergisms between natural agents and antifungal drugs have been published.

Aims

To evaluate the synergistic antifungal effect of glabridin (Gla) and VRC against A. fumigatus isolates.

Methods

Potential interactions between Gla and VRC were studied by using a microdilution checkerboard method based on the CLSI reference technique. To assess the interaction of drugs the fractional inhibitory concentration index (FICI) was calculated based on the Loewe Additivity model.

Results

The minimum inhibitory concentrations (MIC) obtained with Gla alone were relatively high (MIC₅₀ 16 μg/ml). However, our results showed synergistic interaction between Gla and VRC against A. fumigatus strains, with FICI range values between 0.15 and 0.5.

Conclusions

Synergistic activity of Gla and VRC against both VRC-sensitive and -resistant A. fumigatus isolates may lead to design new antifungal agents, especially for inhibiting those azole-resistant strains.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

光甘草定与伏立康唑对烟曲霉的体外相互作用

背景:dvoriconazole (VRC)被广泛推荐为侵袭性曲霉病的一线治疗药物。然而，监测研究表明，在烟熏曲霉分离株中，抗唑频率有所增加。近年来，关于天然药物与抗真菌药物有效协同作用的研究越来越多。目的探讨光甘草定(Gla)与VRC对烟曲霉的协同抑菌作用。方法采用基于CLSI参比技术的微量稀释棋盘法研究Gla与VRC之间可能存在的相互作用。为了评估药物的相互作用，基于Loewe加性模型计算分数抑制浓度指数(FICI)。结果单用Gla获得的最低抑菌浓度(MIC)较高，为16 μg/ml。结果表明，Gla和VRC对烟igatus菌株具有协同作用，FICI值在0.15 ~ 0.5之间。结论Gla和VRC对VRC敏感和耐药烟曲霉的协同作用可能为设计新的抗真菌药物提供依据，特别是对抗唑菌株的抑制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Revista Iberoamericana De Micologia MYCOLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

81 days

期刊介绍： Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.