Latent profile analysis of blood marker phenotypes and their relationships with clinical pain and interference reports in people with acute musculoskeletal trauma.

Joshua Y Lee, David M Walton
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引用次数: 3

Abstract

Background: The prevalence of inadequate treatments for chronic pain has necessitated the search for biological factors that influence the transition to chronicity. Methods: Antecubital blood was drawn from those who experienced acute, noncatastrophic musculoskeletal trauma. Follow-up occurred at 1, 3, 6, and 12 months with the primary outcome being Brief Pain Inventory (BPI) Functional Interference scores. Eight markers were chosen for latent profile analysis: brain-derived neurotrophic factor (BDNF); transforming growth factor-beta 1 (TGF-β1); C-reactive protein (CRP); tumor necrosis factor-alpha (TNF-α); interleukins (ILs) 1-beta, 6, and 10; and the stress hormone cortisol. Results: Mean age of the 106 participants was 44.6 years and 58.5% were female. The final model indicated a three-class solution that could be adequately described by three of the eight markers: class 1 = low concentration of all markers (33.9% of the sample), class 2 = average concentration of all markers (47.7%), and class 3 = high concentration of BDNF and TGF-β1 (18.3%). BPI Pain Interference scores captured at both inception and 6-month follow-up were compared across the three groups. Mean scores were significantly higher in class 3 for the BPI Interference subscale at inception (27.0 [SD 16.4] vs. 35.8 [SD 17.3], P = 0.05) and at 6-month follow-up (2.2 [SD 4.8] vs. 7.3 [SD 10.7], P = 0.03) compared to those of the other two classes. Conclusions: Although recovered populations are not significantly different in BDNF and TGF-β1 levels, those who experience persisting disability are more likely to have moderate to high levels in serum.

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急性肌肉骨骼创伤患者血液标志物表型的潜在分析及其与临床疼痛和干扰报告的关系。
背景:慢性疼痛治疗不充分的普遍现象使得有必要寻找影响向慢性过渡的生物学因素。方法:从经历急性非灾难性肌肉骨骼创伤的患者中抽取肘前血。随访时间分别为1、3、6和12个月,主要结果为短期疼痛量表(BPI)功能干扰评分。选择8种标记物进行潜在谱分析:脑源性神经营养因子(BDNF);转化生长因子β1 (TGF-β1);c反应蛋白(CRP);肿瘤坏死因子α (TNF-α);白细胞介素(il) 1- β、6和10;以及压力荷尔蒙皮质醇。结果:106名参与者的平均年龄为44.6岁,其中58.5%为女性。最终的模型显示了一个可以被8个标记物中的3个充分描述的3类溶液:1类=所有标记物的低浓度(占样本的33.9%),2类=所有标记物的平均浓度(47.7%),3类=高浓度的BDNF和TGF-β1(18.3%)。在开始和6个月的随访中对三组的BPI疼痛干扰评分进行比较。与其他两组相比,第3组在开始时的BPI干扰分量表平均得分(27.0 [SD 16.4]比35.8 [SD 17.3], P = 0.05)和6个月随访时的平均得分(2.2 [SD 4.8]比7.3 [SD 10.7], P = 0.03)均显著高于其他两组。结论:虽然康复人群在BDNF和TGF-β1水平上没有显著差异,但经历持续残疾的人群更有可能在血清中有中高水平。
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来源期刊
CiteScore
3.70
自引率
12.50%
发文量
36
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