{"title":"Attention-Guided Generative Adversarial Network to Address Atypical Anatomy in Synthetic CT Generation.","authors":"Hajar Emami, Ming Dong, Carri K Glide-Hurst","doi":"10.1109/iri49571.2020.00034","DOIUrl":null,"url":null,"abstract":"<p><p>Recently, interest in MR-only treatment planning using synthetic CTs (synCTs) has grown rapidly in radiation therapy. However, developing class solutions for medical images that contain atypical anatomy remains a major limitation. In this paper, we propose a novel spatial attention-guided generative adversarial network (attention-GAN) model to generate accurate synCTs using T1-weighted MRI images as the input to address atypical anatomy. Experimental results on fifteen brain cancer patients show that attention-GAN outperformed existing synCT models and achieved an average MAE of 85.223±12.08, 232.41±60.86, 246.38±42.67 Hounsfield units between synCT and CT-SIM across the entire head, bone and air regions, respectively. Qualitative analysis shows that attention-GAN has the ability to use spatially focused areas to better handle outliers, areas with complex anatomy or post-surgical regions, and thus offer strong potential for supporting near real-time MR-only treatment planning.</p>","PeriodicalId":93159,"journal":{"name":"2020 IEEE 21st International Conference on Information Reuse and Integration for Data Science : IRI 2020 : proceedings : virtual conference, 11-13 August 2020. IEEE International Conference on Information Reuse and Integration (21st : 2...","volume":"2020 ","pages":"188-193"},"PeriodicalIF":0.0000,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/iri49571.2020.00034","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2020 IEEE 21st International Conference on Information Reuse and Integration for Data Science : IRI 2020 : proceedings : virtual conference, 11-13 August 2020. IEEE International Conference on Information Reuse and Integration (21st : 2...","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/iri49571.2020.00034","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/9/10 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 10
Abstract
Recently, interest in MR-only treatment planning using synthetic CTs (synCTs) has grown rapidly in radiation therapy. However, developing class solutions for medical images that contain atypical anatomy remains a major limitation. In this paper, we propose a novel spatial attention-guided generative adversarial network (attention-GAN) model to generate accurate synCTs using T1-weighted MRI images as the input to address atypical anatomy. Experimental results on fifteen brain cancer patients show that attention-GAN outperformed existing synCT models and achieved an average MAE of 85.223±12.08, 232.41±60.86, 246.38±42.67 Hounsfield units between synCT and CT-SIM across the entire head, bone and air regions, respectively. Qualitative analysis shows that attention-GAN has the ability to use spatially focused areas to better handle outliers, areas with complex anatomy or post-surgical regions, and thus offer strong potential for supporting near real-time MR-only treatment planning.