Prevalence of Retinal Vein Occlusions and Estimated Cerebrospinal Fluid Pressure: The Kailuan Eye Study.

IF 3.1 Q1 OPHTHALMOLOGY Eye and Brain Pub Date : 2021-05-21 eCollection Date: 2021-01-01 DOI:10.2147/EB.S290107
Qian Wang, Jingyan Yang, Jost B Jonas, Xuehui Shi, Shouling Wu, Shuohua Chen, Yanni Yan, Wenjia Zhou, Li Dong, Wenbin Wei, Ya Xing Wang
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引用次数: 1

Abstract

Purpose: To investigate the prevalence of retinal vein occlusions (RVOs) and associated factors in a Chinese population.

Patients and methods: The cross-sectional community-based Kailuan Eye Study included individuals who participated in the Kailuan Study. RVOs were diagnosed on the fundus photographs. Estimated cerebrospinal fluid pressure (eCSFP) was calculated as "eCSFP=0.44*Body Mass Index+0.16*Diastolic Blood Pressure-0.18*Age".

Results: The study included 12,499 participants with a mean age of 52.9±13.1 years. The overall prevalence of RVO was 120/12,499 or 0.96%, with branch RVOs observed in 116/12,499 individuals and central RVOs in 4/12,499 individuals. RVOs started at the optic disc in 19 participants (15.8% of all RVOs), and in 101 (84.2%) individuals arterio-venous crossings outside the optic disc. In multivariable analysis, a higher RVO prevalence was associated with older age (P<0.001), higher eCSFP (P<0.001), and higher fasting serum glucose concentration (P<0.001). Differentiating between RVOs at arterio-venous crossings and RVOs at the optic disc revealed that the prevalence of both RVO types was associated with higher eCSFP (P<0.001 and P=0.004, respectively) after adjusting for age and fasting serum glucose concentration.

Conclusion: In this adult Chinese population recruited on a community basis, the prevalence of any RVO (mean: 0.96) was associated with older age, higher eCSFP and higher fasting serum glucose concentration. Higher eCSFP may play an etiologic role in RVOs.

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视网膜静脉阻塞的患病率和估计脑脊液压:开滦眼研究。
目的:调查中国人群视网膜静脉阻塞(RVOs)的患病率及其相关因素。患者和方法:以社区为基础的横断面开滦眼科研究纳入了参加开滦研究的个体。眼底照片诊断RVOs。估计脑脊液压(eCSFP)计算为“eCSFP=0.44*体重指数+0.16*舒张压0.18*年龄”。结果:研究纳入12499名参与者,平均年龄52.9±13.1岁。总体RVO患病率为120/ 12499(0.96%),其中分支RVO发生率为116/ 12499,中心RVO发生率为4/ 12499。19名参与者(占所有RVOs的15.8%)的RVOs开始于视盘,101名(84.2%)的人在视盘外的动静脉交叉。在多变量分析中,在调整年龄和空腹血糖浓度后,较高的RVO患病率与年龄有关(PPPPP分别=0.004)。结论:在社区基础上招募的中国成年人群中,任何RVO的患病率(平均:0.96)与年龄较大、eCSFP较高和空腹血糖浓度较高相关。较高的eCSFP可能在RVOs中起病因学作用。
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来源期刊
Eye and Brain
Eye and Brain OPHTHALMOLOGY-
CiteScore
7.90
自引率
2.30%
发文量
12
审稿时长
16 weeks
期刊介绍: Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.
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