Human Q Fever on the Guiana Shield and Brazil: Recent Findings and Remaining Questions.

IF 3.6 Q2 INFECTIOUS DISEASES Current Tropical Medicine Reports Pub Date : 2021-01-01 Epub Date: 2021-06-01 DOI:10.1007/s40475-021-00243-4
Loïc Epelboin, Carole Eldin, Pauline Thill, Vincent Pommier de Santi, Philippe Abboud, Gaëlle Walter, Alessia Melzani, Paule Letertre-Gibert, Lucas Perez, Magalie Demar, Mathilde Boutrou, Jorlan Fernandes, Julman Rosiris Cermeño, Maria Mercedes Panizo, Stephen Gs Vreden, Félix Djossou, Emmanuel Beillard, Jacobus H de Waard, Elba Regina Sampaio de Lemos
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引用次数: 11

Abstract

Purpose of review: In this review, we report on the state of knowledge about human Q fever in Brazil and on the Guiana Shield, an Amazonian region located in northeastern South America. There is a contrast between French Guiana, where the incidence of this disease is the highest in the world, and other countries where this disease is practically non-existent.

Recent findings: Recent findings are essentially in French Guiana where a unique strain MST17 has been identified; it is probably more virulent than those usually found with a particularly marked pulmonary tropism, a mysterious animal reservoir, a geographical distribution that raises questions.

Summary: Q fever is a bacterial zoonosis due to Coxiella burnetii that has been reported worldwide. On the Guiana Shield, a region mostly covered by Amazonian forest, which encompasses the Venezuelan State of Bolivar, Guyana, Suriname, French Guiana, and the Brazilian State of Amapá, the situation is very heterogeneous. While French Guiana is the region reporting the highest incidence of this disease in the world, with a single infecting clone (MST 117) and a unique epidemiological cycle, it has hardly ever been reported in other countries in the region. This absence of cases raises many questions and is probably due to massive under-diagnosis. Studies should estimate comprehensively the true burden of this disease in the region.

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人类Q热在圭亚那盾和巴西:最近的发现和遗留的问题。
综述目的:在这篇综述中,我们报告了巴西和圭亚那盾(位于南美洲东北部的亚马逊地区)人类Q热的知识状况。在法属圭亚那,这种疾病的发病率是世界上最高的,而在其他国家,这种疾病实际上是不存在的。最近的发现:最近的发现主要是在法属圭亚那,在那里发现了一种独特的菌株MST17;它可能比通常发现的那些具有特别明显的肺向性、神秘的动物宿主、令人质疑的地理分布的病毒更具毒性。摘要:Q热是一种由伯纳克希菌引起的细菌性人畜共患病,在世界范围内已有报道。在圭亚那地盾,一个主要被亚马逊森林覆盖的地区,包括委内瑞拉的玻利瓦尔国、圭亚那、苏里南、法属圭亚那和巴西的阿马佩尔国,情况非常不同。虽然法属圭亚那是世界上报告该病发病率最高的区域,只有一个感染克隆(MST 117)和独特的流行病学周期,但该区域其他国家几乎从未报告过该病。病例的缺失引发了许多问题,可能是由于大量诊断不足。研究应全面估计该地区这种疾病的真正负担。
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来源期刊
Current Tropical Medicine Reports
Current Tropical Medicine Reports Medicine-Infectious Diseases
CiteScore
9.30
自引率
1.90%
发文量
23
期刊介绍: Current Tropical Medicine Reports provides expert views on recent advances in the field of tropical medicine in a clear and readable form. This journal offers reviews by domestic and international contributors that highlight the most important, recent papers and findings related to this specific field. We accomplish this by appointing renowned leaders in major tropical medicine subject areas to select topics addressing virology, bacteriology, parasitology, entomology, immunology, cell and molecular biology, epidemiology, ecology, behavioral science and clinical medicine for review by experts who assess the latest developments and highlight significant papers published over the last few years on their topics. These review articles also stress recently published papers of importance in the references, which are accompanied by annotations explaining their importance. In addition to these Section Editors, our international Editorial Board ensures our journal upholds its standards.
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