Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors-time for new definitions.

IF 5.3 2区医学 Q2 CELL BIOLOGY Skeletal Muscle Pub Date : 2021-07-01 DOI:10.1186/s13395-021-00265-6

Osvaldo Contreras, Fabio M V Rossi, Marine Theret

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引用次数: 2

Abstract

Striated muscle is a highly plastic and regenerative organ that regulates body movement, temperature, and metabolism-all the functions needed for an individual's health and well-being. The muscle connective tissue's main components are the extracellular matrix and its resident stromal cells, which continuously reshape it in embryonic development, homeostasis, and regeneration. Fibro-adipogenic progenitors are enigmatic and transformative muscle-resident interstitial cells with mesenchymal stem/stromal cell properties. They act as cellular sentinels and physiological hubs for adult muscle homeostasis and regeneration by shaping the microenvironment by secreting a complex cocktail of extracellular matrix components, diffusible cytokines, ligands, and immune-modulatory factors. Fibro-adipogenic progenitors are the lineage precursors of specialized cells, including activated fibroblasts, adipocytes, and osteogenic cells after injury. Here, we discuss current research gaps, potential druggable developments, and outstanding questions about fibro-adipogenic progenitor origins, potency, and heterogeneity. Finally, we took advantage of recent advances in single-cell technologies combined with lineage tracing to unify the diversity of stromal fibro-adipogenic progenitors. Thus, this compelling review provides new cellular and molecular insights in comprehending the origins, definitions, markers, fate, and plasticity of murine and human fibro-adipogenic progenitors in muscle development, homeostasis, regeneration, and repair.

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骨骼肌纤维脂肪原细胞的起源、效力和异质性——是时候给出新的定义了。

条纹肌是一种可塑性强、再生性强的器官，它调节身体运动、温度和新陈代谢——所有这些都是个人健康和福祉所需的功能。肌肉结缔组织的主要成分是细胞外基质及其固有的基质细胞，它们在胚胎发育、稳态和再生过程中不断重塑肌肉结缔组织。纤维成脂祖细胞是具有间充质干细胞/基质细胞特性的神秘和转化性肌肉间质细胞。它们通过分泌细胞外基质成分、可扩散细胞因子、配体和免疫调节因子的复杂混合物来塑造微环境，从而成为成年肌肉稳态和再生的细胞哨兵和生理枢纽。纤维成脂祖细胞是专门细胞的谱系前体，包括损伤后活化的成纤维细胞、脂肪细胞和成骨细胞。在这里，我们讨论了当前的研究空白、潜在的药物开发，以及关于纤维脂肪祖细胞起源、效力和异质性的悬而未决的问题。最后，我们利用单细胞技术与谱系追踪相结合的最新进展，统一了基质纤维成脂祖细胞的多样性。因此，这篇引人注目的综述为理解小鼠和人类纤维脂肪生成祖细胞在肌肉发育、稳态、再生和修复中的起源、定义、标志物、命运和可塑性提供了新的细胞和分子见解。

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来源期刊

Skeletal Muscle CELL BIOLOGY-

CiteScore

9.10

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The only open access journal in its field, Skeletal Muscle publishes novel, cutting-edge research and technological advancements that investigate the molecular mechanisms underlying the biology of skeletal muscle. Reflecting the breadth of research in this area, the journal welcomes manuscripts about the development, metabolism, the regulation of mass and function, aging, degeneration, dystrophy and regeneration of skeletal muscle, with an emphasis on understanding adult skeletal muscle, its maintenance, and its interactions with non-muscle cell types and regulatory modulators. Main areas of interest include: -differentiation of skeletal muscle- atrophy and hypertrophy of skeletal muscle- aging of skeletal muscle- regeneration and degeneration of skeletal muscle- biology of satellite and satellite-like cells- dystrophic degeneration of skeletal muscle- energy and glucose homeostasis in skeletal muscle- non-dystrophic genetic diseases of skeletal muscle, such as Spinal Muscular Atrophy and myopathies- maintenance of neuromuscular junctions- roles of ryanodine receptors and calcium signaling in skeletal muscle- roles of nuclear receptors in skeletal muscle- roles of GPCRs and GPCR signaling in skeletal muscle- other relevant aspects of skeletal muscle biology. In addition, articles on translational clinical studies that address molecular and cellular mechanisms of skeletal muscle will be published. Case reports are also encouraged for submission. Skeletal Muscle reflects the breadth of research on skeletal muscle and bridges gaps between diverse areas of science for example cardiac cell biology and neurobiology, which share common features with respect to cell differentiation, excitatory membranes, cell-cell communication, and maintenance. Suitable articles are model and mechanism-driven, and apply statistical principles where appropriate; purely descriptive studies are of lesser interest.