T cell receptor revision and immune repertoire changes in autoimmune diseases.

IF 4.3 4区医学 Q2 IMMUNOLOGY International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-07-09 DOI:10.1080/08830185.2021.1929954

Ronghua Song, Xi Jia, Jing Zhao, Peng Du, Jin-An Zhang

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引用次数: 1

Abstract

Autoimmune disease (AID) is a condition in which the immune system breaks down and starts to attack the body. Some common AIDs include systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes mellitus and so forth. The changes in T-cell receptor (TCR) repertoire have been found in several autoimmune diseases, and may be responsible for the breakdown of peripheral immune tolerance. In this review, we discussed the processes of TCR revision in peripheral immune environment, the changes in TCR repertoire that occurred in various AIDs, and the specifically expanded T cell clones. We hope our discussion can provide insights for the future studies, helping with the discovery of disease biomarkers and expanding the strategies of immune-targeted therapy.HighlightsRestricted TCR repertoire and biased TCR-usage are found in a variety of AIDs.TCR repertoire shows tissue specificity in a variety of AID diseases.The relationship between TCR repertoire diversity and disease activity is still controversial in AIDs.Dominant TCR clonotypes may help to discover new disease biomarkers and expand the strategies of immune-targeted therapy.

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自身免疫性疾病中的T细胞受体修饰和免疫库改变。

自身免疫性疾病(AID)是一种免疫系统崩溃并开始攻击身体的疾病。常见的艾滋病包括系统性红斑狼疮、类风湿性关节炎、1型糖尿病等。t细胞受体(TCR)库的变化已在几种自身免疫性疾病中发现，并可能是外周免疫耐受破坏的原因。在这篇综述中，我们讨论了外周免疫环境中TCR的修改过程，各种艾滋病中TCR库的变化，以及特异性扩增的T细胞克隆。我们希望我们的讨论可以为未来的研究提供见解，帮助发现疾病的生物标志物，扩大免疫靶向治疗的策略。在各种艾滋病中发现了限制TCR曲目和有偏见的TCR使用。TCR库在多种艾滋病疾病中显示出组织特异性。在艾滋病中，TCR库多样性与疾病活动性之间的关系仍然存在争议。显性TCR克隆型可能有助于发现新的疾病生物标志物和扩大免疫靶向治疗策略。

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来源期刊

International Reviews of Immunology 医学-免疫学

CiteScore

11.00

自引率

4.00%

发文量

期刊介绍： This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).