Neurophysiological biomarkers to optimize deep brain stimulation in movement disorders.

IF 2.3 Q3 CLINICAL NEUROLOGY Neurodegenerative disease management Pub Date : 2021-08-01 Epub Date: 2021-07-15 DOI:10.2217/nmt-2021-0002

Daniel Sirica, Angela L Hewitt, Christopher G Tarolli, Miriam T Weber, Carol Zimmerman, Aida Santiago, Andrew Wensel, Jonathan W Mink, Karlo J Lizárraga

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引用次数: 11

Abstract

Intraoperative neurophysiological information could increase accuracy of surgical deep brain stimulation (DBS) lead placement. Subsequently, DBS therapy could be optimized by specifically targeting pathological activity. In Parkinson's disease, local field potentials (LFPs) excessively synchronized in the beta band (13-35 Hz) correlate with akinetic-rigid symptoms and their response to DBS therapy, particularly low beta band suppression (13-20 Hz) and high frequency gamma facilitation (35-250 Hz). In dystonia, LFPs abnormally synchronize in the theta/alpha (4-13 Hz), beta and gamma (60-90 Hz) bands. Phasic dystonic symptoms and their response to DBS correlate with changes in theta/alpha synchronization. In essential tremor, LFPs excessively synchronize in the theta/alpha and beta bands. Adaptive DBS systems will individualize pathological characteristics of neurophysiological signals to automatically deliver therapeutic DBS pulses of specific spatial and temporal parameters.

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优化运动障碍深部脑刺激的神经生理生物标志物。

术中神经生理信息可提高脑深部电刺激(DBS)导联定位的准确性。随后，DBS治疗可以通过特异性靶向病理活性来优化。在帕金森病中，β带(13-35 Hz)过度同步的局部场电位(LFPs)与动力学刚性症状及其对DBS治疗的反应相关，特别是低β带抑制(13-20 Hz)和高频γ促进(35-250 Hz)。在肌张力障碍中，lfp在theta/alpha (4- 13hz)、beta和gamma (60- 90hz)波段异常同步。相性肌张力障碍症状及其对DBS的反应与θ / α同步变化相关。在特发性震颤中，lfp在θ / α和β波段过度同步。自适应DBS系统将个性化神经生理信号的病理特征，自动传递特定时空参数的治疗性DBS脉冲。

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来源期刊

Neurodegenerative disease management CLINICAL NEUROLOGY-

CiteScore

4.30

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0.00%

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