Modulatory Effect of Probiotics on Proinflammatory Cytokine Levels in Acrylamide-Treated Rats.

IF 3.4 Q2 BIOCHEMICAL RESEARCH METHODS Biochemistry Research International Pub Date : 2021-07-20 eCollection Date: 2021-01-01 DOI:10.1155/2021/2268770

Seyed Mohammad Seifati, Erfan Zaker, Farzaneh Fesahat, Fateme Zare, Seyedhossein Hekmatimoghaddam

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引用次数: 2

Abstract

The aims of this study are to investigate the effect of acrylamide on the level of proinflammatory cytokines in the blood of acrylamide-treated rats and to find the modulatory impact of probiotics on those cytokines. Thirty-two rats were divided into four groups: rats which received 20 mg acrylamide, acrylamide with 20 mg probiotics, acrylamide with 200 mg probiotics, and standard water and food (groups 1-4, respectively). The serum levels of cytokines were measured on days 0, 15, and 30. Group 1 showed an increased serum level of IL-1β, IL-6, and TNF-α after 15 days, and they decreased in day 30. Serum IL-6 level was significantly decreased on days 15 and 30 in rats in group 2 compared to the controls. TNF-α and IL-1β levels were not statistically different after treated with probiotics. The exposure of rats to acrylamide led to increased systemic inflammation as evidenced by higher levels of proinflammatory cytokines, and probiotics can modulate this inflammation.

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益生菌对丙烯酰胺处理大鼠促炎细胞因子水平的调节作用。

本研究旨在探讨丙烯酰胺对丙烯酰胺处理大鼠血液中促炎细胞因子水平的影响，并探讨益生菌对这些细胞因子的调节作用。将32只大鼠分为4组:分别给予丙烯酰胺20 mg、丙烯酰胺加益生菌20 mg、丙烯酰胺加益生菌200 mg、标准水和食物(1-4组)。于第0、15、30天测定血清细胞因子水平。第1组小鼠血清IL-1β、IL-6、TNF-α水平在第15天升高，第30天降低。与对照组相比，2组大鼠血清IL-6水平在第15天和第30天显著降低。经益生菌处理后TNF-α和IL-1β水平无统计学差异。大鼠暴露于丙烯酰胺导致全身炎症增加，促炎细胞因子水平升高证明了这一点，而益生菌可以调节这种炎症。

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