A nontoxic ionic liquid composition for the delivery of biological macromolecular anions across the skin barrier.

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pharmaceutical patent analyst Pub Date : 2021-07-01 Epub Date: 2021-08-09 DOI:10.4155/ppa-2021-0012
Neeraj Kumar, Balraj Saini, Rajwinder Kaur
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引用次数: 1

Abstract

The development of biocompatible ionic liquids is needed in order to explore their vastly underutilized pharmaceutical potential. US10912834 patent discloses ionic liquids comprising macromolecular biological anions and alkylated cations, which provides enhanced dermal delivery and cell internalization of the large biological anions. The studies of ex vivo permeation through excised pig skin indicated significantly higher skin penetration of percent dose and enhanced drug internalization was achieved using these ionic liquids. Although, the patent advances an infant field of biological macromolecule-based ionic liquids, the evaluation of these claimed ionic liquids relies only on the in vivo cytotoxicity data and ex vivo skin permeation behavior. Exhaustive studies, including dermatokinetic evaluation and long-term animal toxicity experiments, should be performed in order to unravel the potential of the aforementioned ionic liquids.

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一种无毒离子液体组合物,用于跨越皮肤屏障递送生物大分子阴离子。
生物相容性离子液体的开发是开发其未充分利用的医药潜力的必要条件。US10912834专利公开了包含大分子生物阴离子和烷基化阳离子的离子液体,其提供了增强的大生物阴离子的皮肤递送和细胞内化。通过猪皮肤的离体渗透研究表明,使用这些离子液体可以显著提高百分之百剂量的皮肤渗透,并增强药物的内化。虽然,该专利推进了基于生物大分子的离子液体的婴儿领域,但对这些声称的离子液体的评估仅依赖于体内细胞毒性数据和体外皮肤渗透行为。为了揭示上述离子液体的潜力,应该进行详尽的研究,包括皮肤动力学评估和长期动物毒性实验。
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来源期刊
Pharmaceutical patent analyst
Pharmaceutical patent analyst PHARMACOLOGY & PHARMACY-
CiteScore
1.80
自引率
0.00%
发文量
22
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