Evaluation of fluorohydroxyapatite/strontium coating on titanium implants fabricated by hydrothermal treatment.

IF 4.4 3区医学 Q2 ENGINEERING, BIOMEDICAL Progress in Biomaterials Pub Date : 2021-09-01 Epub Date: 2021-08-09 DOI:10.1007/s40204-021-00162-7

Ahmad Moloodi, Haniyeh Toraby, Saeed Kahrobaee, Morteza Kafaie Razavi, Akram Salehi

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引用次数: 6

Abstract

Titanium and its alloys are considered as appropriate replacements for the irreparable bone. Calcium phosphate coatings are widely used to improve the osteoinduction and osseointegration ability of titanium alloys. To further improve the performance of the calcium phosphate-coated implants, strontium (Sr) was introduced to partially replace the calcium ions. In this study, the effect of Sr ion addition on the fluorohydroxyapatite (FHA)-coated Ti6Al4V alloy was investigated and all the coatings were treated under hydrothermal condition. X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used to investigate the phases and microstructures, respectively. Shear tests were done to evaluate the bond strength of the coating layer. MTT, adhesion, and alkaline phosphatase tests were performed to evaluate the biocompatibility and osteogenic behavior of the samples. Results showed that the average crystallite size for the strontium-doped FHA samples was 48 nm and the bond strength had increased 13.15% in comparison with FHA-coated samples. Analysis of variance showed p value for all MTT tests at more than 0.322 and there was not any evidence of cell death after 7 days. The results of the ALP test showed that the increase of the cell activity in Sr samples from day 7 to 14 is three times higher than the FHA ones.

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水热法制备钛植入体氟羟基磷灰石/锶涂层的研究。

钛及其合金被认为是不可修复骨的合适替代物。磷酸钙涂层被广泛用于提高钛合金的骨诱导和骨整合能力。为了进一步提高磷酸钙包被植入物的性能，引入锶(Sr)来部分取代钙离子。本研究研究了锶离子对氟羟基磷灰石(FHA)涂层Ti6Al4V合金的影响，并在水热条件下对所有涂层进行了处理。采用x射线衍射(XRD)和扫描电镜(SEM)分别对材料的物相和微观结构进行了表征。通过剪切试验对涂层的粘结强度进行了评价。通过MTT、黏附和碱性磷酸酶测试来评估样品的生物相容性和成骨行为。结果表明，掺锶FHA样品的平均晶粒尺寸为48 nm，结合强度比包覆FHA样品提高了13.15%。方差分析显示，所有MTT试验的p值均大于0.322，未发现7天后细胞死亡的证据。ALP试验结果显示，Sr样品在第7 ~ 14天细胞活性的增加是FHA样品的3倍。

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来源期刊

Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

9.60

自引率

4.10%

发文量

期刊介绍： Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.