Botulinum Toxin Type A in the Spasticity of Cerebral Palsy Related to Congenital Zika Syndrome: An Observational Study.

IF 1.1 4区医学 Q4 CLINICAL NEUROLOGY Developmental Neurorehabilitation Pub Date : 2022-04-01 Epub Date: 2021-08-13 DOI:10.1080/17518423.2021.1960917

Giulia Armani-Franceschi, Cleber Luz, Pedro H Lucena, Danilo d'Afonseca, Henrique Sales, Alessandra L Carvalho, Isadora C Siqueira, Karine Silva, Sandra Portuense, Larissa Monteiro, Igor D Bandeira, Ailton Melo, Rita Lucena

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Abstract

Purpose: Investigate the effect of botulinum toxin type-A (BoNT-A) on spasticity and motor performance in children with Cerebral Palsy (CP) related to Congenital Zika Syndrome (CZS).

Methods: Prospective longitudinal observational study of 34 children with CP referred for BoNT-A treatment. Outcomes were evaluated with a muscle tone assessment scale (Modified Ashworth Scale - MAS) and the Patients' Global Impression of Improvement (PGI-I) scale.

Results: Mean age was 32.06 ± 3.07 months and 85% were classified as Gross Motor Function Classification System (GMFCS) V. Primitive reflexes were present in 56% of the sample. The majority of the parents (97.9%) reported improvement in range of motion or reduction in spasticity after treatment with botulinum toxin. No side effects were recorded. When compared to the baseline, median reduction in the MAS was 0.5 (IQR = 0).

Conclusions: The findings of this study suggest that BoNT-A may effectively promote functional improvements and reduce muscle tone, improving the child's and family's quality of life.

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A型肉毒毒素在先天性寨卡综合征相关脑瘫痉挛中的作用:一项观察性研究。

目的:探讨a型肉毒毒素(BoNT-A)对先天性寨卡综合征(CZS)相关脑瘫(CP)患儿痉挛和运动能力的影响。方法:对34例CP患儿行BoNT-A治疗的前瞻性纵向观察研究。采用肌张力评估量表(改良Ashworth量表- MAS)和患者整体改善印象量表(PGI-I)对结果进行评估。结果:平均年龄32.06±3.07个月，85%的患者属于大运动功能分类系统(GMFCS)， 56%的患者存在原始反射。大多数父母(97.9%)报告用肉毒杆菌毒素治疗后活动范围改善或痉挛减少。无副作用记录。与基线相比，MAS的中位降低为0.5 (IQR = 0)。结论:本研究结果表明BoNT-A可以有效促进功能改善，降低肌肉张力，改善儿童和家庭的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental Neurorehabilitation CLINICAL NEUROLOGY-PEDIATRICS

CiteScore

3.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Developmental Neurorehabilitation aims to enhance recovery, rehabilitation and education of people with brain injury, neurological disorders, and other developmental, physical and intellectual disabilities. Although there is an emphasis on childhood, developmental disability can be considered from a lifespan perspective. This perspective acknowledges that development occurs throughout a person’s life and thus a range of impairments or diseases can cause a disability that can affect development at any stage of life.