Changes in anterior segment parameters and presence of dry eye disease in patients with acromegaly: A Sirius topography study combined with meibography

IF 1.6 4区 医学 Q4 CELL BIOLOGY Growth Hormone & Igf Research Pub Date : 2021-10-01 DOI:10.1016/j.ghir.2021.101424
Deniz Kilic , Berkay Akmaz , Fahrettin Akay , Yusuf Ziya Guven , Guzide Gonca Oruk
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引用次数: 2

Abstract

Purpose

To investigate anterior segment parameters (ASPs) and dry eye disease (DED), including the status of the meibomian glands, in patients with acromegaly.

Methods

In this cross-sectional, comparative study, 36 acromegaly patients and 40 healthy sex- and age-matched controls were included. Participants received a comprehensive ophthalmological examination, including intraocular pressure measurements with Goldmann applanation tonometry (IOPGAT) and central corneal thickness corrected intraocular pressure (IOPCCT) measurements, and were evaluated for ASPs and DED. For ASPs, white-to-white (WTW), apical (ACT) and thinnest corneal thickness (TCT), corneal volume (CV), keratometry readings (K1, K2, and Kmean), anterior chamber depth (ACD) and volume (ACV), and iridocorneal angle (ICA) were obtained via Sirius topography. DED was assessed with Schirmer's test, tear breakup time (TBUT), and Ocular Surface Disease Index (OSDI) scores. Meibography scores (MSs) were obtained with the Sirius topography device.

Results

Patients had higher mean IOPGAT (P = .006), IOPCCT (P = .01), ACT (P = .024), and TCT (P = .005) but narrower ICA (P = .014) than controls. Although Schirmer's test did not differ between the groups (P = .442), patients had higher OSDI (P < .001), higher MS (P = .001), and shorter TBUT (P = .002).

Conclusion

Patients with acromegaly have greater IOP, greater corneal thickness, but narrower ICA than healthy individuals, as well as DED with increased MSs, which suggests meibomian gland dysfunction.

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肢端肥大症患者前段参数的变化和干眼病的存在:一项天狼星地形图研究结合meibography
目的探讨肢端肥大症患者前段参数(asp)与干眼症(DED)的关系,包括睑板腺的状态。方法本研究选取36例肢端肥大症患者和40例性别、年龄相匹配的健康对照。参与者接受了全面的眼科检查,包括使用Goldmann眼压计(IOPGAT)测量眼压和中央角膜厚度校正眼压(IOPCCT)测量眼压,并评估asp和DED。对于asp,通过Sirius地形图获得白到白(WTW)、顶(ACT)和最薄角膜厚度(TCT)、角膜体积(CV)、角膜测量读数(K1、K2和Kmean)、前房深度(ACD)和体积(ACV)以及虹膜角膜角(ICA)。采用Schirmer试验、泪液破裂时间(TBUT)和眼表疾病指数(OSDI)评分评估DED。使用Sirius地形仪获得Meibography评分(MSs)。结果患者IOPGAT (P = 0.006)、IOPCCT (P = 0.01)、ACT (P = 0.024)、TCT (P = 0.005)均值高于对照组,ICA (P = 0.014)均值低于对照组。虽然两组间Schirmer检验没有差异(P = .442),但患者的OSDI较高(P <.001), MS较高(P = .001), TBUT较短(P = .002)。结论肢端肥大症患者IOP较大,角膜厚度较大,ICA较正常人窄,且DED伴MSs增高,提示睑板腺功能障碍。
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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
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