Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases.

IF 3.4 Q2 TOXICOLOGY Journal of Toxicology Pub Date : 2021-08-10 eCollection Date: 2021-01-01 DOI:10.1155/2021/9564297

Suryakant Niture, Minghui Lin, Qi Qi, John T Moore, Keith E Levine, Reshan A Fernando, Deepak Kumar

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Abstract

Cadmium (Cd) is a toxic pollutant that is associated with several severe human diseases. Cd can be easily absorbed in significant quantities from air contamination/industrial pollution, cigarette smoke, food, and water and primarily affects the liver, kidney, and lungs. Toxic effects of Cd include hepatotoxicity, nephrotoxicity, pulmonary toxicity, and the development of various human cancers. Cd is also involved in the development and progression of fatty liver diseases and hepatocellular carcinoma. Cd affects liver function via modulation of cell survival/proliferation, differentiation, and apoptosis. Moreover, Cd dysregulates hepatic autophagy, an endogenous catabolic process that detoxifies damaged cell organelles or dysfunctional cytosolic proteins through vacuole-mediated sequestration and lysosomal degradation. In this article, we review recent developments and findings regarding the role of Cd in the modulation of hepatotoxicity, autophagic function, and liver diseases at the molecular level.

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自噬在镉诱发的肝毒性和肝病中的作用

镉（Cd）是一种有毒污染物，与多种严重的人类疾病有关。镉很容易从空气污染/工业污染、香烟烟雾、食物和水中大量吸收，主要影响肝脏、肾脏和肺部。镉的毒性作用包括肝毒性、肾毒性、肺毒性和各种人类癌症的发病。镉还与脂肪肝和肝细胞癌的发生和发展有关。镉通过调节细胞存活/增殖、分化和凋亡来影响肝功能。此外，镉还会使肝脏自噬功能失调，而自噬是一种内源性分解代谢过程，通过液泡介导的固着和溶酶体降解，对受损细胞器或功能失调的细胞膜蛋白质进行解毒。本文回顾了镉在分子水平上调节肝毒性、自噬功能和肝脏疾病方面的最新进展和发现。

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来源期刊

Journal of Toxicology TOXICOLOGY-

CiteScore

5.50

自引率

3.40%

发文量

审稿时长

10 weeks

期刊介绍： Journal of Toxicology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of toxicological sciences. The journal will consider articles looking at the structure, function, and mechanism of agents that are toxic to humans and/or animals, as well as toxicological medicine, risk assessment, safety evaluation, and environmental health.