Experimental animal models for diabetes and its related complications-a review.

IF 2.7 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Laboratory Animal Research Pub Date : 2021-08-24 DOI:10.1186/s42826-021-00101-4
Chidhambara Priya Dharshini Kottaisamy, Divya S Raj, V Prasanth Kumar, Umamaheswari Sankaran
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引用次数: 64

Abstract

Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one of the fastest growing public health problems in the world. It is characterized by hyperglycemia, a condition with high glucose level in the blood plasma resulting from defects in insulin secretion or its action and in some cases both the impairment in secretion and also action of insulin coexist. Historically, animal models have played a critical role in exploring and describing malady pathophysiology and recognizable proof of targets and surveying new remedial specialists and in vivo medicines. In the present study, we reviewed the experimental models employed for diabetes and for its related complications. This paper reviews briefly the broad chemical induction of alloxan and streptozotocin and its mechanisms associated with type 1 and type 2 diabetes. Also we highlighted the different models in other species and other animals.

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糖尿病及其相关并发症的实验动物模型综述
糖尿病是一种非常常见的、多方面的代谢紊乱,被认为是世界上增长最快的公共卫生问题之一。它的特点是高血糖症,一种由于胰岛素分泌或作用缺陷导致的血浆中葡萄糖水平升高的情况,在某些情况下,胰岛素分泌障碍和作用障碍并存。从历史上看,动物模型在探索和描述疾病病理生理学和可识别的靶点证据以及调查新的治疗专家和体内药物方面发挥了关键作用。在本研究中,我们回顾了用于糖尿病及其相关并发症的实验模型。本文综述了四氧嘧啶和链脲佐菌素的广泛化学诱导作用及其与1型和2型糖尿病的相关机制。我们还强调了其他物种和其他动物的不同模式。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
32
审稿时长
8 weeks
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