miR-433-3p Targets AJUBA to Inhibit Malignant Progression of Glioma.

IF 2.2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Neuroimmunomodulation Pub Date : 2022-01-01 Epub Date: 2021-09-10 DOI:10.1159/000518084

Jing Zhang, Yihang Guo, Yanrong Ma, Lipeng Wang, Weiyuan Li, Manyu Zhang, Jiaming Zhao, Yueming Hu, Hongmei Yu, Guozhi Hu

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引用次数: 6

Abstract

Introduction: Glioma is the most aggressive and malignant type of tumors among primary intracranial tumors. miR-433-3p has been verified to be correlated with the formation and progression of many types of cancers.

Methods: In this study, the effects of miR-433-3p and AJUBA on the proliferation, migration, and invasion of glioma and the molecular mechanisms were investigated. We analyzed bioinformatics databases and conducted cell biology experiments to determine that compared with adjacent tissue and normal cells, the expression level of miR-433-3p in glioma tissue and cells was lower, while the expression level of AJUBA was higher. Overexpressing miR-433-3p could significantly inhibit the proliferation, migration, and invasion of glioma cells and promote cell apoptosis.

Results: In addition, after overexpressing miR-433-3p and AJUBA, it was found that overexpressing AJUBA could attenuate the inhibitory effect of overexpressing miR-433-3p on the proliferation, migration, and invasion of glioma cells, which suggested that miR-433-3p regulated the biological function of glioma by downregulating AJUBA expression.

Conclusion: These results proved that miR-433-3p could target to inhibit the expression of AJUBA, thus inhibiting the biological function and malignant progression of glioma.

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miR-433-3p靶向AJUBA抑制胶质瘤恶性进展

胶质瘤是原发性颅内肿瘤中最具侵袭性和恶性的肿瘤类型。miR-433-3p已被证实与多种癌症的形成和发展相关。方法:本研究探讨miR-433-3p和AJUBA对胶质瘤增殖、迁移和侵袭的影响及其分子机制。我们通过分析生物信息学数据库和细胞生物学实验确定，与邻近组织和正常细胞相比，miR-433-3p在胶质瘤组织和细胞中的表达水平较低，而AJUBA的表达水平较高。过表达miR-433-3p可显著抑制胶质瘤细胞的增殖、迁移和侵袭，促进细胞凋亡。结果:此外，在过表达miR-433-3p和AJUBA后，我们发现过表达AJUBA可以减弱过表达miR-433-3p对胶质瘤细胞增殖、迁移和侵袭的抑制作用，这表明miR-433-3p通过下调AJUBA的表达来调节胶质瘤的生物学功能。结论:这些结果证明miR-433-3p可以靶向抑制AJUBA的表达，从而抑制胶质瘤的生物学功能和恶性进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroimmunomodulation 医学-免疫学

CiteScore

3.60

自引率

4.20%

发文量

审稿时长

>12 weeks

期刊介绍： The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.