Aleš Vícha, Lucie Štolová, Pavla Jenčová, Michal Zápotocký, David Sumerauer, Adéla Mišove, Miroslav Koblížek, Petr Brož, Josef Zámečník, Martin Kynčl, Petr Libý, Lenka Krsková
{"title":"Methylation pattern in the diagnosis and prognosis of brain cancer.","authors":"Aleš Vícha, Lucie Štolová, Pavla Jenčová, Michal Zápotocký, David Sumerauer, Adéla Mišove, Miroslav Koblížek, Petr Brož, Josef Zámečník, Martin Kynčl, Petr Libý, Lenka Krsková","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Examination of changes in the methylation profile of DNA in cancer is currently used to determine the diagnosis or prognostic and predictive biomarkers. It complements histological or molecular biological examinations. At the same time, it helps to identify new diagnostic groups and subgroups. Currently, this diagnosis is most common in brain tumors, where it has become a routine examination. The established methylation profile may help even where the diagnosis or subgroup classification of the disease cannot be determined in any other way, as is the case with medulloblastoma.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ceskoslovenska patologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
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Abstract
Examination of changes in the methylation profile of DNA in cancer is currently used to determine the diagnosis or prognostic and predictive biomarkers. It complements histological or molecular biological examinations. At the same time, it helps to identify new diagnostic groups and subgroups. Currently, this diagnosis is most common in brain tumors, where it has become a routine examination. The established methylation profile may help even where the diagnosis or subgroup classification of the disease cannot be determined in any other way, as is the case with medulloblastoma.
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