Animal, Human, and 23Na MRI Imaging Evidence for the Negative Impact of High Dietary Salt in Children.

IF 3.6 Q1 PEDIATRICS Current pediatrics reports Pub Date : 2021-01-01 Epub Date: 2021-09-18 DOI:10.1007/s40124-021-00249-6
Guido Filler, Fabio Salerno, Christopher William McIntyre, Maria E Díaz-González de Ferris
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Abstract

Purpose of the review: Conditions typically prevalent in adults such as hypertension, kidney stones, osteoporosis, and chronic kidney disease are increasing among adolescents and young adults (AYA). The purpose of this review is to describe the association of these conditions to a high salt diet among pediatric patients.

Recent findings: We present animal, human, and 23Na MRI evidence associated with the negative impact of high dietary salt in children. Special focus is placed on novel 23Na MRI imaging which reveals the important concept of a third compartment for sodium storage in soft tissue. Finally, we make recommendations on who should not be on a low salt diet.

Summary: A high salt intake predisposes children and AYA to considerable morbidity. We exhort the reader to engage in advocacy efforts to curve the incidence and prevalence of high salt-related life-limiting conditions.

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动物、人类和 23Na MRI 成像证明高膳食盐对儿童的负面影响。
审查目的:高血压、肾结石、骨质疏松症和慢性肾病等通常在成人中流行的疾病在青少年中的发病率越来越高。本综述旨在描述这些疾病与儿科患者高盐饮食的关系:我们介绍了与儿童高盐饮食负面影响相关的动物、人类和 23Na MRI 证据。我们特别关注了新型 23Na MRI 成像,该成像揭示了软组织中钠储存的第三空间这一重要概念。最后,我们就哪些人不应该采用低盐饮食提出了建议。摘要:高盐摄入容易导致儿童和青壮年大量发病。我们呼吁读者参与宣传工作,以降低与高盐有关的限制生命疾病的发病率和流行率。
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