Effects of Chlorophytum borivilianum Sant. F against gamma radiation-induced testicular injuries in Swiss albino mice.

Ayu Pub Date : 2020-01-01 Epub Date: 2021-07-30 DOI:10.4103/ayu.AYU_82_20
Ruchi Vyas, Garima Sharma, Devki Sain, Rashmi Sisodia
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引用次数: 2

Abstract

Background: Radiation therapy is considered as an important tool in cancer treatment. Despite its impressive role in treating cancer, severe side effects in organs have been reported. To address these therapeutic side effects, several combination methods have been identified to minimize adverse effects caused by radiation therapy.

Aims and objectives: Based on higher radioactive sensitivity of testicular tissues, administration of Chlorophytum borivilianum (CB) Sant. F extracts was evaluated for its protective effects against radiation in testis.

Materials and methods: Two forms of CB extracts (CB alone and CB-silver nanoparticles [AgNPs]) were administered at a dose of 50 mg/kg body weight in Swiss albino male mice for 7 consecutive days. Following 6 Gy gamma radiation, animals were observed for 30 days in four phases. Sperm counts, body weight, testicular weight and stereological and histological evaluation of testis were evaluated.

Results: Following irradiation, a significant decline in body weight (P = 0.008) and testicular weight (P = 0.001) was noted when compared with control. Ununiformed type A and B spermatogonia, partially filled tubules, inter-tubular vacuoles, and disrupted epithelium were the main types of damages caused by irradiation. Reorganization and resumption of histological features emerged from the 15th day postirradiation in CB extract (CBE)-treated animals.

Conclusion: Testicular response was observed against radiation in animals treated with CB extracts, while CB-AgNPs indicated better toleration when compared to CB extract alone.

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绿吊兰对植物生长的影响。F抗γ射线致瑞士白化小鼠睾丸损伤。
背景:放射治疗被认为是癌症治疗的重要手段。尽管它在治疗癌症方面的作用令人印象深刻,但据报道,它对器官有严重的副作用。为了解决这些治疗副作用,已经确定了几种联合方法来最大限度地减少放射治疗引起的副作用。目的和目的:基于睾丸组织较高的放射性敏感性,给予吊兰(CB) Sant。评价了F提取物对睾丸辐射的保护作用。材料与方法:以50 mg/kg体重的剂量,连续7天给药两种形式的CB提取物(CB单独和CB-银纳米颗粒[AgNPs])。在6 Gy γ射线照射后,动物分为四个阶段观察30天。评估精子数量、体重、睾丸重量以及睾丸的体视学和组织学评价。结果:与对照组相比,放疗后大鼠体重(P = 0.008)和睾丸重量(P = 0.001)明显下降。A型和B型精原细胞不均匀、小管部分充盈、小管间空泡、上皮破坏是辐照引起的主要损伤类型。放射后第15天,CB提取物(CBE)处理的动物出现了组织学特征的重组和恢复。结论:用CB提取物治疗的动物睾丸对辐射有反应,而CB- agnps与单独使用CB提取物相比表现出更好的耐受性。
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