Sorafenib Induced Complete Cytogenetic and Molecular Response in a Chronic Eosinophilic Leukemia Case with t(12;13) Translocation.

Abstract

Hypereosinophilia (HE) is defined as a persistent increase in absolute eosinophil counts (AEC) to levels >1.5 × 109/L. HE can be ‘primary’ or ‘secondary’, more often accompanying infections, allergic disorders, autoimmune diseases or myeloproliferative/lymphoproliferative neoplasms [1,2]. In 2016, the WHO revised the classification of eosinophilic disorders, distinguishing myeloid/lymphoid neoplasms with eosinophilia and recurrent genetic lesions (such as rearrangement of PDGFRA, PDGFRB, FGFR1 and PCM1-JAK2), chronic eosinophilic leukemia (CEL) not otherwise specified (NOS), and idiopathic HE [3,4].