Lu Liu, Hua Dong, Xiaoneng Jin, Katherine Brooke-Wavell
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引用次数: 5
Abstract
Background and purpose: Dementia prevalence is expected to increase dramatically with population aging. As a nonpharmacological therapy, physical activity is an appealing alternative to tackling aging and dementia. However, contradictions were found in previous studies. The aim of this systematic review is to gather the latest evidence of the effects of physical activity interventions on cognition and noncognitive functions of older people with dementia.
Methods: PubMed, Cochrane, and Web of Science databases were searched to identify relevant studies. We followed the PRISMA guidelines to identify randomized controlled trials that reported original findings of physical activity interventions on older people with dementia (≥65 years of age). These studies were published in English between January 1, 2009 and November 9, 2019.
Results: In total, 16 trials with 2085 participants were included in the review. Compared to baseline, cognitive function improved significantly in 2 studies, deteriorated in 3 studies, and remained stable in 11 studies. In the exercise relative to the control group, 5 studies showed no significant differences, 2 studies showed significantly greater deterioration in cognition, and 9 studies showed significantly greater improvement in cognition. However, most studies (n = 13.81%) had notable limitations (eg, with a high risk of bias, limited follow-up time, or unexplained high heterogeneity in their findings). Fourteen studies reported a positive impact on one or more areas of physical function, mobility, activities of daily living, depression levels, and behavioral/psychological symptoms of dementia.
Conclusions: Physical activity interventions have a positive impact on physical function, mobility, and activities of daily living. However, the available evidence is insufficient to support the conclusion that physical activity improves cognitive function of older people with dementia.
背景与目的:随着人口老龄化,痴呆患病率预计将急剧上升。作为一种非药物疗法,体育活动是解决衰老和痴呆的一种有吸引力的选择。然而,在以往的研究中发现了矛盾。本系统综述的目的是收集身体活动干预对老年痴呆患者认知和非认知功能影响的最新证据。方法:检索PubMed、Cochrane和Web of Science数据库,确定相关研究。我们遵循PRISMA指南来确定随机对照试验,这些试验报告了身体活动干预对老年痴呆患者(≥65岁)的原始发现。这些研究在2009年1月1日至2019年11月9日期间以英文发表。结果:共纳入16项试验,2085名受试者。与基线相比,2项研究的认知功能明显改善,3项研究的认知功能恶化,11项研究的认知功能保持稳定。在运动方面,与对照组相比,5项研究无显著差异,2项研究认知功能明显恶化,9项研究认知功能明显改善。然而,大多数研究(n = 13.81%)存在明显的局限性(例如,偏倚风险高,随访时间有限,或研究结果存在无法解释的高异质性)。14项研究报告了对身体功能、机动性、日常生活活动、抑郁水平和痴呆症的行为/心理症状的一个或多个领域的积极影响。结论:身体活动干预对身体功能、活动能力和日常生活活动有积极影响。然而,现有证据不足以支持体育活动改善老年痴呆症患者认知功能的结论。
期刊介绍:
Journal of Geriatric Physical Therapy is the leading source of clinically applicable evidence for achieving optimal health, wellness, mobility, and physical function across the continuum of health status for the aging adult.
The mission of the Academy of Geriatric Physical Therapy is building a community that advances the profession of physical therapy to optimize the experience of aging.