Adjusting to precarity: how and why the Roslin Institute forged a leading role for itself in international networks of pig genomics research.

IF 0.7 1区 哲学 Q2 HISTORY & PHILOSOPHY OF SCIENCE British Journal for the History of Science Pub Date : 2021-12-01 DOI:10.1017/S0007087421000686
James W E Lowe
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引用次数: 3

Abstract

From the 1980s onwards, the Roslin Institute and its predecessor organizations faced budget cuts, organizational upheaval and considerable insecurity. Over the next few decades, it was transformed by the introduction of molecular biology and transgenic research, but remained a hub of animal geneticists conducting research aimed at the livestock-breeding industry. This paper explores how these animal geneticists embraced genomics in response to the many-faceted precarity that the Roslin Institute faced, establishing it as a global centre for pig genomics research through forging and leading the Pig Gene Mapping Project (PiGMaP); developing and hosting resources, such as a database for genetic linkage data; and producing associated statistical and software tools to analyse the data. The Roslin Institute leveraged these resources to play a key role in further international collaborations as a hedge against precarity. This adoption of genomics was strategically useful, as it took advantage of policy shifts at the national and European levels towards funding research with biotechnological potential. As genomics constitutes a set of infrastructures and resources with manifold uses, the development of capabilities in this domain also helped Roslin to diversify as a response to precarity.

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适应不稳定:罗斯林研究所如何以及为什么在猪基因组学研究的国际网络中为自己树立了领导地位。
从20世纪80年代开始,罗斯林研究所及其前身面临着预算削减、组织动荡和相当大的不安全感。在接下来的几十年里,由于引入了分子生物学和转基因研究,它发生了变化,但仍然是动物遗传学家进行牲畜养殖业研究的中心。本文探讨了这些动物遗传学家如何接受基因组学来应对罗斯林研究所面临的多方面的不稳定性,通过建立和领导猪基因定位项目(PiGMaP),将其建立为猪基因组学研究的全球中心;开发和托管资源,例如遗传连锁数据数据库;并产生相关的统计和软件工具来分析数据。罗斯林研究所利用这些资源,在进一步的国际合作中发挥关键作用,以防范不稳定。基因组学的采用在战略上是有用的,因为它利用了国家和欧洲层面的政策转变,为具有生物技术潜力的研究提供资金。由于基因组学构成了一套具有多种用途的基础设施和资源,该领域能力的发展也有助于罗斯林实现多样化,以应对不稳定性。
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来源期刊
CiteScore
0.80
自引率
12.50%
发文量
59
期刊介绍: This leading international journal publishes scholarly papers and review articles on all aspects of the history of science. History of science is interpreted widely to include medicine, technology and social studies of science. BJHS papers make important and lively contributions to scholarship and the journal has been an essential library resource for more than thirty years. It is also used extensively by historians and scholars in related fields. A substantial book review section is a central feature. There are four issues a year, comprising an annual volume of over 600 pages. Published for the British Society for the History of Science
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