Early microvascular changes in patients with prediabetes evaluated by optical coherence tomography angiography.

IF 2.3 Q2 OPHTHALMOLOGY Therapeutic Advances in Ophthalmology Pub Date : 2021-10-21 eCollection Date: 2021-01-01 DOI:10.1177/25158414211047020
Juan D Arias, Francisco J Arango, Maria Margarita Parra, Ronald M Sánchez-Ávila, Gustavo A Parra-Serrano, Andrea T Hoyos, Silvia J Granados, Eduardo J Viteri, Ivetteh Gaibor-Santos, Yanny Perez
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引用次数: 4

Abstract

Background: Timely detection of early microvascular changes in patients with prediabetes could help reduce the likelihood of progression of diabetes-related retinal complications.

Aim: To determine early microvascular changes in patients with prediabetes using optical coherence tomography angiography (OCT-A).

Methods: In this single-center retrospective case-control study, macular OCT-A images of superficial capillary plexus (SCP) and deep capillary plexus (DCP) were analyzed in non-diabetic controls, and prediabetic and diabetic subjects. A quantitative analysis was performed using ImageJ software of the foveal avascular zone (FAZ) area, acircularity index (AI), perfusion density (PD), and vascular length density (VLD).

Results: A total of 94 eyes of 53 patients were included in this study. The global mean age was 57.7 years, 39.6% men and 60.4% women. In SCP, the mean PD was 0.283 ± 0.15, 0.186 ± 0.720, and 0.186 ± 0.07 in non-diabetic controls, and prediabetic and diabetic groups, respectively. The mean VLD was 8.728 ± 3.425 in non-diabetic controls, 6.147 ± 1.399 in prediabetic group, and 6.292 ± 1.997 in patients with diabetes. The comparison of prediabetic patients and controls shows statistical differences between PD and VLD in both plexus SCP (p = 0.002 and p = 0.001, respectively) and DCP (p = 0.005 and p = 0.002, respectively). The mean area of FAZ in patients with diabetes and normal individuals was 0.281 and 0.196 mm2, respectively (p < 0.001). AI was higher in the control group (0.87 ± 0.14) and prediabetic group (0.80 ± 0.17) compared to diabetic patients (0.64 ± 0.19). There were no differences in FAZ area and AI between prediabetic and non-diabetic controls.

Conclusion: PD and VLD demonstrated to be early microvascular changes in prediabetic patients evaluated by OCT-A. No alterations of FAZ were evidenced in this group.

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光学相干断层扫描血管造影评价糖尿病前期患者早期微血管变化。
背景:及时发现糖尿病前期患者的早期微血管变化有助于降低糖尿病相关视网膜并发症进展的可能性。目的:利用光学相干断层扫描血管造影(OCT-A)检测糖尿病前期患者的早期微血管变化。方法:在单中心回顾性病例对照研究中,分析非糖尿病对照组、糖尿病前期和糖尿病患者黄斑浅毛细血管丛(SCP)和深毛细血管丛(DCP)的OCT-A图像。采用ImageJ软件定量分析中央凹无血管区(FAZ)面积、循环指数(AI)、灌注密度(PD)、血管长度密度(VLD)。结果:本研究共纳入53例患者94只眼。全球平均年龄为57.7岁,男性占39.6%,女性占60.4%。在SCP中,非糖尿病对照组、糖尿病前期和糖尿病组的平均PD分别为0.283±0.15、0.186±0.720和0.186±0.07。非糖尿病对照组平均VLD为8.728±3.425,糖尿病前期组为6.147±1.399,糖尿病组为6.292±1.997。糖尿病前期患者与对照组比较,PD和VLD在神经丛SCP (p = 0.002和p = 0.001)和DCP (p = 0.005和p = 0.002)均有统计学差异。糖尿病患者和正常人FAZ的平均面积分别为0.281和0.196 mm2 (p)。结论:OCT-A评价糖尿病前期患者PD和VLD为早期微血管改变。本组未见FAZ改变。
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CiteScore
4.50
自引率
0.00%
发文量
44
审稿时长
12 weeks
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