{"title":"[Tumor budding in colorectal cancer-Information for clinical use and instructions for practical evaluation].","authors":"Felix Müller, Alessandro Lugli, Heather Dawson","doi":"10.1007/s00292-021-01016-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Some patients with high-risk colorectal cancer show a worse prognosis within the same UICC stage. Therefore, the identification of additional risk factors is necessary to find the best treatment for these patients.</p><p><strong>Objective: </strong>In which settings can tumor budding help the clinical decision-making process for treatment planning and how should scoring be performed?</p><p><strong>Material and methods: </strong>Evaluation of current publications on tumor budding with an emphasis on practical grading and potential problems in the determination of tumor budding.</p><p><strong>Results: </strong>Tumor budding is a significant risk factor for worse clinical outcome of colorectal cancer and can influence clinical decision-making in pT1 and stage II colorectal cancer. A scoring method was standardized by the ITBCC 2016 and is feasible in everyday practice. Challenges in assessment can be addressed by increasing awareness of potential problem cases.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 1","pages":"45-50"},"PeriodicalIF":0.0000,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789725/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathologe","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00292-021-01016-6","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/11/1 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Some patients with high-risk colorectal cancer show a worse prognosis within the same UICC stage. Therefore, the identification of additional risk factors is necessary to find the best treatment for these patients.
Objective: In which settings can tumor budding help the clinical decision-making process for treatment planning and how should scoring be performed?
Material and methods: Evaluation of current publications on tumor budding with an emphasis on practical grading and potential problems in the determination of tumor budding.
Results: Tumor budding is a significant risk factor for worse clinical outcome of colorectal cancer and can influence clinical decision-making in pT1 and stage II colorectal cancer. A scoring method was standardized by the ITBCC 2016 and is feasible in everyday practice. Challenges in assessment can be addressed by increasing awareness of potential problem cases.
期刊介绍：
Der Pathologe is an internationally recognized journal and combines practical relevance with scientific competence. The journal informs all pathologists working on departments and institutes as well as morphologically interested scientists about developments in the field of pathology.
The journal serves both the scientific exchange and the continuing education of pathologists.
Comprehensive reviews on a specific topical issue focus on providing evidenced based information under consideration of practical experience.
Freely submitted original papers allow the presentation of important clinical studies and serve the scientific exchange.
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