Application of dermal regenerative template in reconstructing skin defects after plantar malignant melanoma excision.

Q2 Medicine Journal of Buon Pub Date : 2021-09-01

Xuanlong Zhang, Yute Sun, Zuoqiong Hou, Binlin Luo, Chujun Li, Keyu Jiang, Jinfang Liu, Gang Yao, Jian Tang

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Abstract

Purpose: The excision of plantar malignant melanoma frequently leads to wide skin defects on the plantar surface. This study aimed to investigate the advantages and feasibility of dermal regenerative template reconstructing plantar blemishes caused by malignant melanoma.

Methods: 28 patients identified with plantar malignant melanoma were included in this retrospective article. Eighteen patients received immediate skin grafts after wide excision skin graft (SG) group), whereas the remaining 10 patients were treated with dermal regenerative template (DRT) (Lando ®, Shenzhen TsingCare Medical Co. Ltd) 14 days before skin grafts (DRT group) and the postoperative survival rate in the two groups was analyzed. During the 6-month follow-up, we compared the scar index, plantar pain, and recurrent skin graft ulcer incidence on the skin grafts area.

Results: Postoperative survival rate in the DRT group (91.75% ± 7.64%) was higher than in the SG group (80.51% ± 7.17%). The DRT group showed less scar formation on Vancouver scar scale (VSS index): 3.40 ± 1.07 than the SG group (VSS index: 6.33 ± 0.68). The dermal regenerative template alleviated plantar pain and decreased the incidence of ulcer on the skin grafts area.

Conclusions: The dermal regenerative template not only improves the survival rate of skin grafts but also alleviates scar condition, plantar pain and recurrent skin graft ulcer. This study provides a new reconstructive strategy in plantar skin defects after the excision of malignant melanoma.

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真皮再生模板在足底恶性黑色素瘤切除术后皮肤缺损重建中的应用。

目的:足底恶性黑色素瘤的切除常导致足底表面广泛的皮肤缺损。本研究旨在探讨真皮再生模板修复恶性黑色素瘤足底缺陷的优势和可行性。方法:回顾性分析28例足底恶性黑色素瘤患者。18例患者接受大面积切除后即刻植皮(SG)组，其余10例患者在植皮前14天接受皮肤再生模板(DRT)(兰多®，深圳青山医疗有限公司)治疗(DRT组)，分析两组患者的术后生存率。在6个月的随访中，我们比较了植皮区瘢痕指数、足底疼痛和复发性植皮溃疡的发生率。结果:DRT组术后生存率(91.75%±7.64%)高于SG组(80.51%±7.17%)。温哥华疤痕评分(VSS指数):DRT组瘢痕形成较少，为3.40±1.07，低于SG组(VSS指数:6.33±0.68)。真皮再生模板减轻了足底疼痛，减少了植皮区溃疡的发生率。结论:真皮再生模板不仅提高了植皮成活率，而且减轻了瘢痕状况、足底疼痛和复发性植皮溃疡。本研究为恶性黑色素瘤切除后足底皮肤缺损的修复提供了一种新的修复策略。

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来源期刊

Journal of Buon 医学-肿瘤学

自引率

0.00%

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审稿时长

4-8 weeks

期刊介绍： JBUON aims at the rapid diffusion of scientific knowledge in Oncology. Its character is multidisciplinary, therefore all aspects of oncologic activities are welcome including clinical research (medical oncology, radiation oncology, surgical oncology, nursing oncology, psycho-oncology, supportive care), as well as clinically-oriented basic and laboratory research, cancer epidemiology and social and ethical aspects of cancer. Experts of all these disciplines are included in the Editorial Board. With a rapidly increasing body of new discoveries in clinical therapeutics, the molecular mechanisms that contribute to carcinogenesis, advancements in accurate and early diagnosis etc, JBUON offers a free forum for clinicians and basic researchers to make known promptly their achievements around the world. With this aim JBUON accepts a broad spectrum of articles such as editorials, original articles, reviews, special articles, short communications, commentaries, letters to the editor and correspondence among authors and readers. JBUON keeps the characteristics of its former paper print edition and appears as a bimonthly e-published journal with continuous volume, issue and page numbers.