Drug repurposing of adapalene for melanoma treatment.

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pharmaceutical patent analyst Pub Date : 2022-01-01 Epub Date: 2022-02-16 DOI:10.4155/ppa-2021-0021
Maricruz Anaya-Ruiz, Martin Perez-Santos
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引用次数: 2

Abstract

Cancer drug repurposing is an attractive approach that leads to savings in time and investment. Adapalene, the first medical application of which was for the treatment of acne, has been described as a repurposing drug for the treatment of various types of cancer. Patent application CN111329851 describes the use of adapalene for the treatment of melanoma, by assays carried out on melanoma cell lines. Adapalene demonstrated antiproliferative activity in melanoma cell lines via S-phase arrest-dependent apoptosis mediated by DNA damage through an increase in the expression of p-ATM and p-chk2 and a decrease in the expression of p-BRCA1 and Rad51. Even though no evidence on efficacy and efficiency is shown in preclinical and clinical studies, CN111329851 patent shows that adapalene may be a repurposing drug for the treatment of melanoma.

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阿达帕林用于黑色素瘤治疗的药物再利用。
癌症药物再利用是一种有吸引力的方法,可以节省时间和投资。阿达帕林,它的第一个医学应用是治疗痤疮,被描述为一种用于治疗各种类型癌症的重新用途药物。专利申请CN111329851描述了通过对黑素瘤细胞系进行测定来治疗黑素瘤的阿达帕烯的使用。阿达帕林通过增加p-ATM和p-chk2的表达以及降低p-BRCA1和Rad51的表达,在DNA损伤介导的s期阻滞依赖性细胞凋亡中显示出抗增殖活性。尽管在临床前和临床研究中没有疗效和效率的证据,但CN111329851专利表明,阿达帕林可能是治疗黑色素瘤的一种再利用药物。
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来源期刊
Pharmaceutical patent analyst
Pharmaceutical patent analyst PHARMACOLOGY & PHARMACY-
CiteScore
1.80
自引率
0.00%
发文量
22
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