Intradural Extramedullary Ewing Sarcoma in an Adolescent Female.

Adolescent Health, Medicine and Therapeutics Pub Date : 2022-02-15 eCollection Date: 2022-01-01 DOI:10.2147/AHMT.S349975
Mikkel Kunwald, Christian Lund Straszek, Carsten Reidies Bjarkam, Marianne Schmidt Ettrup, Torjus Skajaa, Janus Laust Thomsen, Mikkel Thusgaard, Morten Zebitz Steiness
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Abstract

A 15-year-old female experiencing lumbar pain without prior trauma. Despite being prescribed strong analgesics by her family physician, the symptoms intensified, and she was referred to diagnostic imaging. Magnetic resonance imaging revealed an intradural extramedullary tumor in the spinal canal, located behind the L3 corpora. The patient underwent neurosurgery with a complete resection of the tumor. The histopathologic examination revealed Ewing sarcoma by identifying EWSR1 gene in the extracted tissue. The patient was subsequently referred for extensive specialized oncological treatment including photon irradiation therapy and chemotherapy. Thirty-six months on from the initial diagnosis, the patient is doing well and suffers no sequelae apart from hypogonadism.

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1例青春期女性硬膜内髓外尤文氏肉瘤。
一名15岁女性,无外伤,腰痛。尽管她的家庭医生给她开了强效镇痛药,但她的症状还是加重了,她被转介到诊断影像科。磁共振成像显示椎管内硬膜内髓外肿瘤,位于L3体后方。病人接受了神经外科手术,完全切除了肿瘤。组织病理学检查发现提取组织中存在EWSR1基因,为尤文氏肉瘤。患者随后接受了广泛的专科肿瘤治疗,包括光子照射治疗和化疗。从最初的诊断,36个月以来,病人做得很好,没有后遗症,除了性腺功能减退。
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