Watermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male Wistar rats

IF 2.1 Q3 PHYSIOLOGY Current research in physiology Pub Date : 2021-01-01 DOI:10.1016/j.crphys.2021.11.002

Olugbenga S. Michael , Olubayode Bamidele , Pamela Ogheneovo , Temitope A. Ariyo , Lawrence D. Adedayo , Olufemi I. Oluranti , Elizabeth O. Soladoye , Charles O. Adetunji , Funmileyi O. Awobajo

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引用次数: 1

Abstract

Lead acetate associated tissue injury has been linked to altered antioxidant defenses, hyperuricemia and inflammation. We hypothesized that watermelon rind extract, would ameliorate lead acetate-induced hepato-renal injury.

Thirty Male Wistar rats received distilled water, lead acetate (Pb; 5 mg/kg) with or without watermelon rind extract (WM; 400 mg/kg; WM + Pb; 15 days of WM pretreatment); Pb + WM (15 days of WM post treatment) and simultaneous treatment (WM-Pb) for 30 days.

Lead toxicity led to elevated serum malondialdehyde, creatinine, urea, uric acid, lactate dehydrogenase, liver injury enzymes, as well as decreased body weight. Decreased serum levels of reduced glutathione, nitric oxide, total protein and glutathione peroxidase activity was also observed. However, these alterations were ameliorated by watermelon rind extract in lead acetate-treated rats.

Watermelon rind ethanol extract protects against lead acetate-induced hepato-renal injury through improved antioxidant defenses at least in part, via uric acid/nitric oxide-dependent pathway signifying the health benefits of this agricultural waste and a potential for waste recycling while limiting environmental pollution.

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西瓜皮乙醇提取物对铅诱导的雄性Wistar大鼠抗氧化能力受损具有肝肾保护作用

与醋酸铅相关的组织损伤与抗氧化防御改变、高尿酸血症和炎症有关。我们假设西瓜皮提取物可以改善醋酸铅引起的肝肾损伤。30只雄性Wistar大鼠接受蒸馏水、醋酸铅(Pb;5 mg/kg)，含或不含西瓜皮提取物(WM;400毫克/公斤;WM + Pb;WM预处理15 d);Pb + WM (WM处理后15 d)和同时处理(WM-Pb) 30 d。铅中毒导致血清丙二醛、肌酐、尿素、尿酸、乳酸脱氢酶、肝损伤酶升高，体重下降。血清还原性谷胱甘肽、一氧化氮、总蛋白水平和谷胱甘肽过氧化物酶活性均下降。然而，西瓜皮提取物可改善醋酸铅处理大鼠的这些改变。西瓜皮乙醇提取物至少在一定程度上通过尿酸/一氧化氮依赖途径改善抗氧化防御，防止醋酸铅诱导的肝肾损伤，这表明这种农业废物对健康有益，并有可能在限制环境污染的同时回收废物。

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