{"title":"Mathematical analysis of a cancer model with time-delay in tumor-immune interaction and stimulation processes.","authors":"Kaushik Dehingia, Hemanta Kumar Sarmah, Yamen Alharbi, Kamyar Hosseini","doi":"10.1186/s13662-021-03621-4","DOIUrl":null,"url":null,"abstract":"<p><p>In this study, we discuss a cancer model considering discrete time-delay in tumor-immune interaction and stimulation processes. This study aims to analyze and observe the dynamics of the model along with variation of vital parameters and the delay effect on anti-tumor immune responses. We obtain sufficient conditions for the existence of equilibrium points and their stability. Existence of Hopf bifurcation at co-axial equilibrium is investigated. The stability of bifurcating periodic solutions is discussed, and the time length for which the solutions preserve the stability is estimated. Furthermore, we have derived the conditions for the direction of bifurcating periodic solutions. Theoretically, it was observed that the system undergoes different states if we vary the system's parameters. Some numerical simulations are presented to verify the obtained mathematical results.</p>","PeriodicalId":53311,"journal":{"name":"Advances in Difference Equations","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546790/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Difference Equations","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.1186/s13662-021-03621-4","RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/10/26 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Mathematics","Score":null,"Total":0}
引用次数: 0
Abstract
In this study, we discuss a cancer model considering discrete time-delay in tumor-immune interaction and stimulation processes. This study aims to analyze and observe the dynamics of the model along with variation of vital parameters and the delay effect on anti-tumor immune responses. We obtain sufficient conditions for the existence of equilibrium points and their stability. Existence of Hopf bifurcation at co-axial equilibrium is investigated. The stability of bifurcating periodic solutions is discussed, and the time length for which the solutions preserve the stability is estimated. Furthermore, we have derived the conditions for the direction of bifurcating periodic solutions. Theoretically, it was observed that the system undergoes different states if we vary the system's parameters. Some numerical simulations are presented to verify the obtained mathematical results.
期刊介绍：
The theory of difference equations, the methods used, and their wide applications have advanced beyond their adolescent stage to occupy a central position in applicable analysis. In fact, in the last 15 years, the proliferation of the subject has been witnessed by hundreds of research articles, several monographs, many international conferences, and numerous special sessions.
The theory of differential and difference equations forms two extreme representations of real world problems. For example, a simple population model when represented as a differential equation shows the good behavior of solutions whereas the corresponding discrete analogue shows the chaotic behavior. The actual behavior of the population is somewhere in between.
The aim of Advances in Difference Equations is to report mainly the new developments in the field of difference equations, and their applications in all fields. We will also consider research articles emphasizing the qualitative behavior of solutions of ordinary, partial, delay, fractional, abstract, stochastic, fuzzy, and set-valued differential equations.
Advances in Difference Equations will accept high-quality articles containing original research results and survey articles of exceptional merit.
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