Fast dissolving nanofiber mat for the local antimicrobial application of roxithromycin in oral cavity

IF 8.1 1区 工程技术 Q1 MATERIALS SCIENCE, BIOMATERIALS Materials science & engineering. C, Materials for biological applications Pub Date : 2021-12-01 DOI:10.1016/j.msec.2021.112537
Sungyun Kim , Jung-Jin Kim , Jae-Hyeon Jeong , Yonghoon Kim , JiHye Park , Da In Jeong , Hyun Jin Kim , ChaeRim Hwang , Sung-Hoon Ahn , Hyun-Jeong Ko , Hyun-Jong Cho
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引用次数: 2

Abstract

Fast disintegrating and dissolving nanofiber (NF) mat was devised to deliver roxithromycin for the treatment of the respiratory tract infection. NF membrane was made by an electrospinning process with poly(vinyl alcohol) (PVA), hydroxypropyl-β-cyclodextrin (HP-β-CD), and d-α-tocopheryl polyethylene glycol succinate (TPGS) for local application of roxithromycin. Roxithromycin has a poor water solubility thus HP-β-CD is introduced for enhancing drug solubility by forming an inclusion complex in this study. The addition of TPGS provided multiple roles such as accelerating wetting, disintegration, and dissolution speed and overcoming bacterial resistance. Roxithromycin was successfully entrapped in NF structure and drug amorphization occurred during the electrospinning process. PVA/HP-β-CD/TPGS/roxithromycin (PHTR) NF exhibited faster wetting, disintegration, and dissolution speed rather than the other NF mats. PHTR NF displayed higher antibacterial potentials in Gram-negative bacteria (E. coli) and Gram-positive bacteria (S. aureus) compared to other NF mat formulations. The administration of PHTR NF to oral cavity in pneumococcal disease mouse model provided the most efficient therapeutic potentials in lung tissue. Designed multiple phase-based NF mat may be one of powerful local drug delivery systems for the therapy of respiratory tract infection.

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快速溶解纳米纤维垫在罗红霉素口腔局部抗菌中的应用
设计了快速崩解溶解纳米纤维(NF)垫,用于递送罗红霉素治疗呼吸道感染。以聚乙烯醇(PVA)、羟丙基-β-环糊精(HP-β-CD)和d-α-生育酚基聚乙二醇琥珀酸酯(TPGS)为原料,采用静电纺丝法制备了局部应用罗红霉素的纳滤膜。罗红霉素的水溶性较差,因此本研究引入HP-β-CD通过形成包合物来提高药物的溶解度。TPGS的加入具有加速润湿、崩解和溶解速度以及克服细菌耐药性等多种作用。罗红霉素被成功地包裹在NF结构中,在静电纺丝过程中发生了药物非晶化。PVA/HP-β-CD/TPGS/roxithromycin (PHTR) NF具有较快的润湿、崩解和溶出速度。PHTR NF对革兰氏阴性菌(大肠杆菌)和革兰氏阳性菌(金黄色葡萄球菌)的抑菌效果优于其他NF NF制剂。在肺炎球菌病小鼠模型中,PHTR NF口腔给药在肺组织中提供了最有效的治疗潜力。设计的多相NF垫可能是治疗呼吸道感染的一种有效的局部给药系统。
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来源期刊
CiteScore
12.60
自引率
0.00%
发文量
28
审稿时长
3.3 months
期刊介绍: Materials Today is a community committed to fostering the creation and sharing of knowledge and experience in materials science. With the support of Elsevier, this community publishes high-impact peer-reviewed journals, organizes academic conferences, and conducts educational webinars, among other initiatives. It serves as a hub for advancing materials science and facilitating collaboration within the scientific community.
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