Ethiopian medicinal plants used for their anti-inflammatory, wound healing or anti-infective activities: protocol for systematic literature review and meta-analysis.

Q1 Medicine BMJ Open Science Pub Date : 2020-09-03 eCollection Date: 2020-01-01 DOI:10.1136/bmjos-2020-100064

Dereje Nigussie, Belete Adefris Legesse, Gail Davey, Abebaw Fekadu, Eyasu Makonnen

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Abstract

Objectives: Medicinal plants are used globally as alternative medicines in the management of a range of disease conditions and are widely accepted across differing societies. Ethiopia hosts a large number of plant species (>7000 higher plant species), of which around 12% are thought to be endemic, making it a rich source of plant extracts potentially useful for human health. The aim of this review is to evaluate Ethiopian medicinal plants for their anti-inflammatory, wound healing, antifungal or antibacterial activities.

Methods and analysis: The guidance of the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) statement will be used. This review will consider all controlled studies of anti-inflammatory and wound healing properties (both in vivo and in vitro) and in vitro anti-infective properties of medicinal plants found in Ethiopia. Data sources will be EMBASE, PubMed/Medline, Scopus and Google Scholar. Guidance documents on good in vitro methods and checklists for reporting in vitro studies will be used for quality assessment of in vitro studies. The risk of bias tool for animal intervention studies (the SYRCLE RoB tool) will be used to assess the validity of studies. The main outcomes will be percent inhibition of inflammation, time of epithelisation and tissue tensile strength in wounds and microbial growth inhibition.

Ethics and dissemination: The findings of this systematic review will be disseminated by publishing in a peer-reviewed journal and via conference presentations. Ethical clearance was obtained from the Brighton and Sussex Medical School, Research Governance & Ethics Committee (RGEC) and Addis Ababa University, College of Health Science, Institutional Review Board.

Prospero registration number: This systematic literature review has been registered with PROSPERO (registration number CRD42019127471).

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埃塞俄比亚用于消炎、伤口愈合或抗感染的药用植物：系统文献综述和荟萃分析规程。

目的：药用植物在全球范围内被用作治疗各种疾病的替代药物，并在不同社会中被广泛接受。埃塞俄比亚拥有大量植物物种（超过 7000 种高等植物物种），其中约 12% 被认为是当地特有物种，这使其成为可能有益于人类健康的植物提取物的丰富来源。本综述旨在评估埃塞俄比亚药用植物的消炎、伤口愈合、抗真菌或抗菌活性：本综述将采用《系统综述和元分析协议首选报告项目》（PRISMA-P）声明的指导。本综述将考虑所有关于埃塞俄比亚发现的药用植物的抗炎和伤口愈合特性（体内和体外）以及体外抗感染特性的对照研究。数据来源包括 EMBASE、PubMed/Medline、Scopus 和 Google Scholar。体外研究质量评估将使用良好体外方法指导文件和体外研究报告核对表。动物干预研究的偏倚风险工具（SYRCLE RoB 工具）将用于评估研究的有效性。主要结果将包括炎症抑制率、伤口上皮化时间和组织拉伸强度以及微生物生长抑制率：本系统综述的研究结果将通过在同行评审期刊上发表和会议演讲的方式进行传播。本研究获得了布莱顿和苏塞克斯医学院研究管理与伦理委员会（RGEC）和亚的斯亚贝巴大学健康科学学院机构审查委员会的伦理许可：本系统文献综述已在 PROSPERO 注册（注册号为 CRD42019127471）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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