Pharmacodynamic interaction of Tinospora cordifolia Willd. With Ocimum sanctum Linn. in isoproterenol-induced cardiac toxicity.

Ayu Pub Date : 2020-04-01 Epub Date: 2021-10-23 DOI:10.4103/ayu.AYU_127_19
Chetan Savant, V H Kulkarni, P V Habbu, Preeti V Kulkarni, Muhammed Majeed, Mahadeva Nayak
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Abstract

Background: Cardiovascular diseases are the leading causes of deaths despite several advancements in the current medical interventions. Among them, myocardial infarction (MI) is the most alarming disease as about 17.1 million peoples die every year due to MI.

Aim: The present study was designed to investigate the potential cardioprotective effect of combination of standardized extracts of Tinospora cordifolia (SETC) (250 mg/kg and 500 mg/kg) and Ocimum sanctum (SEOS) (50 mg/kg) in isoproterenol (ISO)-induced MI.

Materials and methods: MI was induced in rats by subcutaneous injection of ISO for 2 consecutive days at an interval of 24 h. Rats were pretreated with test drugs for the period of 21 days, and ISO was administered on the 20th and 21st days. At the end of experiment, i.e., on 22nd-day electrocardiograph, a hemodynamic, biochemical, and histopathological study of heart tissues was evaluated from control and experimental groups and statistically analyzed by one-way analysis of variance followed by Tukey's test.

Results: ISO-administered rats showed significant changes in electrocardiograph, mean arterial blood pressure, heart rate, biochemical markers, antioxidant parameters, and histopathology of heart. The activities of cardiac biomarkers were reduced in serum, and there was an increase in antioxidants in heart tissue of test drug-treated animals. Similarly, electrocardiograph, mean arterial blood pressure, and heart rate were restored to normalcy in all test and standard drug-treated animals.

Conclusion: The SETC 500 mg/kg in combination with SEOS 50 mg/kg was found to be effective in prevention of myocardial injury induced by ISO.

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堇叶Tinospora cordifolia Willd的药效学相互作用。和至圣林一起。异丙肾上腺素引起的心脏毒性。
背景:尽管目前的医疗干预措施取得了一些进展,但心血管疾病仍是导致死亡的主要原因。其中,心肌梗死(MI)是最令人担忧的疾病,每年约有1710万人因心肌梗死而死亡。目的:探讨异丙肾上腺素(ISO)诱导的心肌梗死中,Tinospora cordifolia (SETC) (250 mg/kg和500 mg/kg)和Ocimum sanctum (SEOS) (50 mg/kg)联合使用的潜在心脏保护作用。采用连续2天皮下注射ISO诱导大鼠心肌梗死,间隔24 h,给药21天,第20、21天给药ISO。实验结束即第22天心电图时,分别对对照组和实验组进行心脏组织血流动力学、生化和组织病理学研究,采用单因素方差分析及Tukey检验进行统计学分析。结果:给药大鼠心电图、平均动脉血压、心率、生化指标、抗氧化指标及心脏组织病理学均有显著变化。实验动物血清中心脏生物标志物活性降低,心脏组织中抗氧化剂含量增加。同样,所有试验动物和标准药物治疗动物的心电图、平均动脉血压和心率均恢复正常。结论:SETC 500 mg/kg联合SEOS 50 mg/kg可有效预防ISO所致心肌损伤。
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