Pharmaceutical Management for Subarachnoid Hemorrhage.

Arnav Barpujari, Chhaya Patel, Rebecca Zelmonovich, Alec Clark, Devan Patel, Kevin Pierre, Kyle Scott, Brandon Lucke Wold
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Abstract

Aneurysmal subarachnoid hemorrhage can have deleterious consequences. Vasospasm, delayed cerebral ischemia, and re-hemorrhage can all cause delayed sequelae. Furthermore, severe headaches are common and require careful modulation of pain medications. Limited treatment options currently exist and are becoming more complex with the rising use of oral anticoagulants needing reversal. In this review, we highlight the current treatment options currently employed and address avenues of future discovery based on emerging preclinical data. Furthermore, we dive into the best treatment approach for managing headaches following subarachnoid hemorrhage. The review is designed to serve as a catalyst for further prospective investigation into this important topic.

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蛛网膜下腔出血的药物治疗。
动脉瘤性蛛网膜下腔出血会造成有害后果。血管痉挛、延迟性脑缺血和再出血都会造成延迟性后遗症。此外,严重头痛也很常见,需要谨慎使用止痛药物。目前的治疗方案有限,而且随着需要逆转的口服抗凝剂使用量的增加而变得更加复杂。在本综述中,我们将重点介绍目前采用的治疗方案,并根据新出现的临床前数据探讨未来的发现途径。此外,我们还深入探讨了治疗蛛网膜下腔出血后头痛的最佳治疗方法。本综述旨在促进对这一重要课题的进一步前瞻性研究。
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