Medication-related osteonecrosis of the jaw: Prosthodontic considerations

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Japanese Dental Science Review Pub Date : 2022-11-01 DOI:10.1016/j.jdsr.2021.11.005

Islam E. Ali , Yuka Sumita

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引用次数: 7

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) can be triggered by several antiresorptive and antiangiogenic medications, including bisphosphonates (BRONJ), denosumab (DRONJ), and other agents used to treat osteoporosis and metastatic bone cancer. Prosthodontists and surgeons continue to face new challenges because of this condition. Despite the current evidence showing that extensive surgical intervention and laser surgery have the highest healing rates, surgical reconstruction is not always possible for large jaw defects requiring prosthetic reconstruction. Moreover, surgical treatment may not be an option in some patients because of other medical conditions. In these patients, MRONJ may develop into a chronic disease with limited resolution and they may seek prosthetic rehabilitation for aesthetic and functional reasons. Therefore, prosthetic intervention may be necessary for some patients with MRONJ even in the absence of a surgical defect. Denture trauma has been reported to be a risk factor for MRONJ, and few reports have discussed the prosthodontic considerations needed for patients with this condition. The aim of this review is to highlight the prosthodontic considerations that would decrease the risk of triggering MRONJ in susceptible patients.

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与药物相关的颌骨骨坏死:修复学的考虑

药物相关性颌骨骨坏死(MRONJ)可由几种抗吸收和抗血管生成药物触发，包括双膦酸盐(BRONJ)、地诺单抗(DRONJ)和其他用于治疗骨质疏松症和转移性骨癌的药物。由于这种情况，修复专家和外科医生继续面临新的挑战。尽管目前的证据表明，广泛的外科干预和激光手术具有最高的治愈率，但对于需要假体重建的大颌骨缺损，手术重建并不总是可行的。此外，由于其他医疗条件，一些患者可能无法选择手术治疗。在这些患者中，MRONJ可能发展为一种慢性疾病，治疗有限，他们可能出于美学和功能原因寻求假肢康复。因此，对于一些MRONJ患者，即使没有手术缺陷，也可能需要假体干预。据报道，义齿创伤是MRONJ的一个危险因素，但很少有报道讨论这种情况下患者需要考虑的修复措施。本综述的目的是强调在易感患者中降低触发MRONJ风险的修复注意事项。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Dental Science Review DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

9.90

自引率

1.50%

发文量

审稿时长

32 days

期刊介绍： The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.