Origin and evolutionary analysis of the SARS-CoV-2 Omicron variant

Q1 Social Sciences Journal of Biosafety and Biosecurity Pub Date : 2022-06-01 DOI:10.1016/j.jobb.2021.12.001
Yamin Sun , Wenchao Lin , Wei Dong , Jianguo Xu
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引用次数: 73

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved rapidly into new variants throughout the pandemic. The Omicron variant has more than 50 mutations when compared with the original wild-type strain and has been identified globally in numerous countries. In this report, we analyzed the mutational profiles of several variants, including the per-site mutation rate, to determine evolutionary relationships. The Omicron variant was found to have a unique mutation profile when compared with that of other SARS-CoV-2 variants, containing mutations that are rare in clinical samples. Moreover, the presence of five mouse-adapted mutation sites suggests that Omicron may have evolved in a mouse host. Mutations in the Omicron receptor-binding domain (RBD) region, in particular, have potential implications for the ongoing pandemic.

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SARS-CoV-2组粒变异的起源和进化分析
在整个大流行期间,严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)迅速演变成新的变体。与原始野生型菌株相比,Omicron变体有50多个突变,并已在全球许多国家被发现。在本报告中,我们分析了几种变异的突变概况,包括每个位点的突变率,以确定进化关系。与其他SARS-CoV-2变体相比,发现Omicron变体具有独特的突变谱,其中包含临床样本中罕见的突变。此外,五个小鼠适应突变位点的存在表明,Omicron可能是在小鼠宿主中进化而来的。特别是组粒受体结合域(RBD)区域的突变,对当前的大流行具有潜在影响。
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来源期刊
Journal of Biosafety and Biosecurity
Journal of Biosafety and Biosecurity Social Sciences-Linguistics and Language
CiteScore
6.00
自引率
0.00%
发文量
20
审稿时长
41 days
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