The Impact of Uremic Toxins on Alzheimer's Disease.

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Current Alzheimer research Pub Date : 2022-01-01 DOI:10.2174/1567205019666220120113305
Yuqi Zheng, Bin Ji, Sijun Chen, Rong Zhou, Ruiqing Ni
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Abstract

Alzheimer's disease (AD) is the most common type of dementia, pathologically characterized by the accumulation of senile plaques and neurofibrillary tangles. Chronic kidney disease (CKD) is highly prevalent in the elderly population closely associated with the occurrence of dementia. Recent epidemiological and experimental studies suggest a potential association of CKD with AD. Both diseases share a panel of identical risk factors, such as type 2 diabetes and hypertension. However, the relationship between CKD and AD is unclear. Lower clearance of a panel of uremic toxin including cystatin- C, guanidine, and adiponectin due to CKD is implied to contribute to AD pathogenesis. In this review, we summarize the current evidence from epidemiological, experimental, and clinical studies on the potential contribution of uremic toxins to AD pathogenesis. We describe outstanding questions and propose an outlook on the link between uremic toxins and AD.

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尿毒症毒素对阿尔茨海默病的影响。
阿尔茨海默病(AD)是最常见的痴呆症类型,其病理特征是老年斑和神经原纤维缠结的积累。慢性肾脏疾病(CKD)在老年人群中高度流行,与痴呆的发生密切相关。最近的流行病学和实验研究表明CKD与AD有潜在的联系。这两种疾病都有相同的风险因素,比如2型糖尿病和高血压。然而,CKD与AD之间的关系尚不清楚。CKD导致的一组尿毒症毒素(包括胱抑素- C、胍和脂联素)的清除率较低,可能与AD的发病有关。在这篇综述中,我们总结了目前流行病学、实验和临床研究中关于尿毒症毒素在AD发病中的潜在作用的证据。我们描述了悬而未决的问题,并提出了对尿毒症毒素和AD之间的联系的展望。
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来源期刊
Current Alzheimer research
Current Alzheimer research 医学-神经科学
CiteScore
4.00
自引率
4.80%
发文量
64
审稿时长
4-8 weeks
期刊介绍: Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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