Implications of Aspirin for Melanoma Treatment: A Short Perspective.

Journal of molecular genetics and medicine Pub Date : 2017-01-01 Epub Date: 2017-08-17
Anita Thyagarajan, Ravi P Sahu
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Abstract

Several human cancers including melanoma exhibit increased expression of inflammatory cyclooxygenases (COX) enzymes that catalyze the conversion of arachidonic acid to prostaglandins (PGs) implicated in tumor growth. As aspirin has been used in the treatment of various ailments including inflammatory diseases, and cancers due to its anti-inflammatory property via inhibiting COX enzymes its significance particularly in reducing the risk of advanced stage or metastatic melanoma has yielded mixed responses. This mini review addresses some of the discrepancies of implications of aspirin from preclinical and clinical studies, and recent updates into its mechanisms of actions in melanoma treatment.

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阿司匹林对黑色素瘤治疗的影响:一个简短的观点。
包括黑色素瘤在内的几种人类癌症表现出炎症环氧合酶(COX)的表达增加,这种酶催化花生四烯酸转化为前列腺素(pg),与肿瘤生长有关。由于阿司匹林通过抑制COX酶的抗炎特性已被用于治疗各种疾病,包括炎症性疾病和癌症,其重要性,特别是在降低晚期或转移性黑色素瘤的风险方面产生了不同的反应。这篇小型综述解决了阿司匹林在临床前和临床研究中的一些差异,以及最近对其在黑色素瘤治疗中的作用机制的更新。
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Implications of Aspirin for Melanoma Treatment: A Short Perspective.
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