Jianmin Huang, Yanfang Yun, Haiyan Chen, Guixin Yang, Yongming Jiang, Yaoxin Pan, Shengshan Yuan, Jianjun Huang, Li Su, Yingning Wu, Dong Lu, Anding Xu, Xuebin Li
{"title":"Association of <i>PON-1</i> polymorphism with susceptibility to and severity of ischemic stroke in the Chinese population.","authors":"Jianmin Huang, Yanfang Yun, Haiyan Chen, Guixin Yang, Yongming Jiang, Yaoxin Pan, Shengshan Yuan, Jianjun Huang, Li Su, Yingning Wu, Dong Lu, Anding Xu, Xuebin Li","doi":"10.2217/pme-2021-0133","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> The authors aimed to investigate whether polymorphisms of <i>PON-1</i> were associated with the susceptibility to and severity of ischemic stroke (IS). <b>Methods:</b> In this study, 302 IS patients and 303 healthy controls were enrolled. Polymorphisms rs854560 and rs854572 of <i>PON-1</i> were detected using SNaPshot single-nucleotide polymorphism typing technology. <b>Results:</b> The rs854572 polymorphism of the <i>PON-1</i> gene showed a significant correlation with IS, and its GG genotype reduced the risk of IS (recessive model, p = 0.001). The GG genotype was also associated with mild stroke (p = 0.032). No association was observed between rs854560 and IS. <b>Conclusion:</b><i>PON-1</i> rs854572 polymorphism was related to the risk of IS and could be a biomarker to access the severity of IS.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Personalized medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2217/pme-2021-0133","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/31 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 3
Abstract
Aim: The authors aimed to investigate whether polymorphisms of PON-1 were associated with the susceptibility to and severity of ischemic stroke (IS). Methods: In this study, 302 IS patients and 303 healthy controls were enrolled. Polymorphisms rs854560 and rs854572 of PON-1 were detected using SNaPshot single-nucleotide polymorphism typing technology. Results: The rs854572 polymorphism of the PON-1 gene showed a significant correlation with IS, and its GG genotype reduced the risk of IS (recessive model, p = 0.001). The GG genotype was also associated with mild stroke (p = 0.032). No association was observed between rs854560 and IS. Conclusion:PON-1 rs854572 polymorphism was related to the risk of IS and could be a biomarker to access the severity of IS.
期刊介绍：
Personalized Medicine (ISSN 1741-0541) translates recent genomic, genetic and proteomic advances into the clinical context. The journal provides an integrated forum for all players involved - academic and clinical researchers, pharmaceutical companies, regulatory authorities, healthcare management organizations, patient organizations and others in the healthcare community. Personalized Medicine assists these parties to shape thefuture of medicine by providing a platform for expert commentary and analysis.
The journal addresses scientific, commercial and policy issues in the field of precision medicine and includes news and views, current awareness regarding new biomarkers, concise commentary and analysis, reports from the conference circuit and full review articles.
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