Myeloid Metabolism as a New Target for Rejuvenation?-Comments on Restoring Metabolism of Myeloid Cells Reverses Cognitive Decline in Ageing. Nature. 2021 Feb;590(7844):122-128.

Immunometabolism Pub Date : 2021-10-31 eCollection Date: 2021-01-01 DOI:10.20900/immunometab20210034
Marlen Knobloch, Rosa C Paolicelli
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引用次数: 1

Abstract

Research led by Katrin Andreasson suggests that fixing age-induced metabolic defects in myeloid cells would suffice to reverse cognitive impairment and to restore synaptic plasticity to the level of young subjects, at least in mice. This opens up the possibility to develop rejuvenating strategies by targeting immune dysfunction.

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髓细胞代谢是恢复活力的新目标?恢复骨髓细胞的代谢可以逆转衰老过程中的认知衰退。Nature. 2021 Feb;590(7844):122-128。
由Katrin Andreasson领导的研究表明,修复髓细胞中由年龄引起的代谢缺陷足以逆转认知障碍,并将突触可塑性恢复到年轻受试者的水平,至少在小鼠中是这样。这为开发针对免疫功能障碍的恢复活力策略提供了可能性。
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