{"title":"[Pathology of hepatocellular carcinoma].","authors":"Thomas Longerich, Peter Schirmacher","doi":"10.1007/s00292-021-01038-0","DOIUrl":null,"url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) represents the third leading cause of cancer-related mortality worldwide and has a well-defined etiology. It develops in a stepwise process with morphologically defined precursor lesions. Typing of highly differentiated hepatocellular tumors is supported by immunohistological marker panel and the so-called matrix diagnosis. The recent World Health Organization (WHO) classification defined morpho-molecular HCC subtypes showing typical clinical and prognostic characteristics. If HCC subtyping is considered in future clinical studies of advanced HCC, this could help to introduce personalized HCC therapy. Currently, precision oncology is not available for HCC.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 1","pages":"67-78"},"PeriodicalIF":0.0000,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathologe","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00292-021-01038-0","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/4 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 1
Abstract
Hepatocellular carcinoma (HCC) represents the third leading cause of cancer-related mortality worldwide and has a well-defined etiology. It develops in a stepwise process with morphologically defined precursor lesions. Typing of highly differentiated hepatocellular tumors is supported by immunohistological marker panel and the so-called matrix diagnosis. The recent World Health Organization (WHO) classification defined morpho-molecular HCC subtypes showing typical clinical and prognostic characteristics. If HCC subtyping is considered in future clinical studies of advanced HCC, this could help to introduce personalized HCC therapy. Currently, precision oncology is not available for HCC.
期刊介绍：
Der Pathologe is an internationally recognized journal and combines practical relevance with scientific competence. The journal informs all pathologists working on departments and institutes as well as morphologically interested scientists about developments in the field of pathology.
The journal serves both the scientific exchange and the continuing education of pathologists.
Comprehensive reviews on a specific topical issue focus on providing evidenced based information under consideration of practical experience.
Freely submitted original papers allow the presentation of important clinical studies and serve the scientific exchange.
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