A Review of Functional Neuroimaging in People with Down Syndrome with and without Dementia.

IF 1.4 Q4 CLINICAL NEUROLOGY Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2021-12-27 eCollection Date: 2021-09-01 DOI:10.1159/000520880

Funmi Deinde, Jay Kotecha, Lilian Suh Lih Lau, Sagnik Bhattacharyya, Latha Velayudhan

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引用次数: 1

Abstract

Background: Individuals with Down syndrome (DS) are at high risk of dementia which is difficult to diagnose in DS. Neuroimaging has been identified as a potential tool to aid diagnosis by detecting changes in brain function. We carried out a review comparing functional neuroimaging in DS individuals with and without dementia.

Summary: A literature search was conducted using PubMed to identify relevant studies. In DS subjects with dementia, fluorodeoxyglucose-positron emission tomography (PET) studies showed glucose hypometabolism particularly in the parietal and/or temporal regions whilst magnetic resonance spectroscopy studies showed increased myoinositol and decreased N-acetylaspartate. Ligand-based PET studies revealed significant Pittsburgh compound B binding in DS subjects over the age of 40, particularly if they had dementia.

Key messages: Neuroimaging may aid the early detection of dementia in DS; however, further longitudinal studies are required.

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唐氏综合征伴及不伴痴呆患者的功能神经影像学研究综述。

背景:唐氏综合征(DS)患者发生痴呆的风险高，且痴呆的诊断难度大。神经成像已经被认为是一种潜在的工具，可以通过检测大脑功能的变化来帮助诊断。我们进行了一项综述，比较了伴有和不伴有痴呆的退行性痴呆患者的功能神经影像学。摘要:通过PubMed进行文献检索，找出相关研究。在患有痴呆症的DS受试者中，氟脱氧葡萄糖正电子发射断层扫描(PET)研究显示葡萄糖代谢低下，特别是在顶叶和/或颞区，而磁共振波谱研究显示肌醇增加，n -乙酰天冬氨酸减少。基于配体的PET研究显示，在40岁以上的DS受试者中，匹兹堡化合物B结合显著，特别是如果他们患有痴呆症。关键信息:神经影像学可能有助于退行性痴呆的早期发现;然而，还需要进一步的纵向研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dementia and Geriatric Cognitive Disorders Extra Medicine-Psychiatry and Mental Health

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： This open access and online-only journal publishes original articles covering the entire spectrum of cognitive dysfunction such as Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field. Dementia and Geriatric Cognitive Disorders Extra provides additional contents based on reviewed and accepted submissions to the main journal Dementia and Geriatric Cognitive Disorders Extra .