{"title":"[Diagnostic and predictive markers in urinary tract cytology].","authors":"Tatjana Vlajnic, Lukas Bubendorf","doi":"10.1007/s00292-022-01053-9","DOIUrl":null,"url":null,"abstract":"<p><p>Multiprobe fluorescence in situ hybridization (FISH) still remains the gold standard for clarifying inconclusive atypia in urinary cytology in daily routine practice. The Paris Classification System (The Paris System, TPS) provides an important basis for the specific indication of FISH and emphasizes the importance of morphological correlation for an integrative approach to diagnosis. Next-generation sequencing technology in urinary specimens, which is highly sensitive for simultaneous detection of multiple genetic alterations, is also likely to play a diagnostic role in the near future.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 2","pages":"99-104"},"PeriodicalIF":0.0000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888376/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathologe","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00292-022-01053-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/2/8 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Multiprobe fluorescence in situ hybridization (FISH) still remains the gold standard for clarifying inconclusive atypia in urinary cytology in daily routine practice. The Paris Classification System (The Paris System, TPS) provides an important basis for the specific indication of FISH and emphasizes the importance of morphological correlation for an integrative approach to diagnosis. Next-generation sequencing technology in urinary specimens, which is highly sensitive for simultaneous detection of multiple genetic alterations, is also likely to play a diagnostic role in the near future.
在日常工作中，多探针荧光原位杂交（FISH）仍是明确尿液细胞学中不确定非典型的金标准。巴黎分类系统（The Paris System，TPS）为 FISH 的具体指征提供了重要依据，并强调了形态学相关性对于综合诊断方法的重要性。尿液标本中的下一代测序技术具有高灵敏度，可同时检测多种基因改变，在不久的将来也可能在诊断中发挥作用。
期刊介绍：
Der Pathologe is an internationally recognized journal and combines practical relevance with scientific competence. The journal informs all pathologists working on departments and institutes as well as morphologically interested scientists about developments in the field of pathology.
The journal serves both the scientific exchange and the continuing education of pathologists.
Comprehensive reviews on a specific topical issue focus on providing evidenced based information under consideration of practical experience.
Freely submitted original papers allow the presentation of important clinical studies and serve the scientific exchange.
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