Subjective clustering in patients with fronto-temporal dementia.

IF 1.7 4区 心理学 Applied Neuropsychology-Adult Pub Date : 2024-03-01 Epub Date: 2022-01-11 DOI:10.1080/23279095.2021.2002867
Roberta Perri, Lucia Fadda, Carlo Caltagirone, Giovanni A Carlesimo
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Abstract

In the behavioral variant of frontotemporal dementia (bvFTD) memory deficits have been traditionally considered as due to difficulties in encoding/retrieval frontal strategies. However, the frontal origin of memory deficits in bvFTD has been questioned and hippocampal dysfunction has been also proposed. Here we analyzed bvFTD patients' proficiency in subjectively organizing memories without an external criterion. Twenty bvFTD patients and 20 healthy individuals were assessed with memory and executive tasks. The ability to subjectively organize memories in the immediate recall of a 15 unrelated word list was measured by calculating the index of subjective clustering (ISC) based on the constancies in response order across the five consecutive free recall trials. Results revealed reduced ISC in bvFTD patients with respect to normal controls. In the bvFTD group, the ISC score correlated with the Corsi span backward score and the number of categories achieved on the Modified Card Sorting Test. The bvFTD patients' reduced ISC and its correlation with executive performance suggest that executive deficits underlie their defective strategic organization of memories. However, as ISC did not predict memory accuracy in these patients, the memory deficit may not be the mere expression of their executive difficulties.

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额颞叶痴呆症患者的主观聚类。
在额颞叶痴呆的行为变异型(bvFTD)中,记忆缺陷历来被认为是由于编码/检索额叶策略的困难造成的。然而,也有人质疑 bvFTD 记忆缺陷的额叶起源,并提出了海马功能障碍的观点。在此,我们分析了bvFTD患者在没有外部标准的情况下主观组织记忆的能力。我们对 20 名 bvFTD 患者和 20 名健康人进行了记忆和执行任务评估。通过计算主观聚类指数(ISC),根据连续五次自由回忆试验中反应顺序的恒定性,测量了在立即回忆 15 个无关单词列表时主观组织记忆的能力。结果显示,与正常对照组相比,bvFTD 患者的 ISC 降低了。在 bvFTD 组中,ISC 分值与 Corsi 跨度后向分值和改良卡片分类测试的类别数相关。bvFTD患者的ISC降低及其与执行力表现的相关性表明,执行力缺陷是他们记忆策略组织缺陷的根源。然而,由于ISC并不能预测这些患者的记忆准确性,因此记忆缺陷可能并不仅仅是他们执行困难的表现。
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来源期刊
Applied Neuropsychology-Adult
Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY
自引率
11.80%
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0
审稿时长
>12 weeks
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