Dental arches in inherited severe isolated growth hormone deficiency

IF 1.6 4区 医学 Q4 CELL BIOLOGY Growth Hormone & Igf Research Pub Date : 2022-02-01 DOI:10.1016/j.ghir.2022.101444
Rafaela S. Girão , Manuel H. Aguiar-Oliveira , Bruna M.R. Andrade , Marcos A.V. Bittencourt , Roberto Salvatori , Evânio V. Silva , André L.M. Santos , Matheus M. Cunha , Wilton M. Takeshita , Alaíde H.A. Oliveira , Eugênia H.O. Valença , Alécia A. Oliveira-Santos , Luiz A. Oliveira-Neto
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引用次数: 4

Abstract

Objectives

The growth of the dental arches depends on GH and insulin-like growth factor type 1 (IGF1), but the consequences of GH deficiency (GHD) on their growth are still unclear, probably due to the acquired etiology of GHD in most described series, often associated with additional pituitary deficits (thyrotrophic, corticotrophic and gonadotrophic hormones), and imperfections of related replacement therapies, which may affect the dental arch growth. To avoid these limitations, we took advantage of a unique cohort of subjects with isolated GH deficiency (IGHD) due the same mutation in the GH releasing hormone receptor gene, living with very low serum GH and low to undetectable circulating IGF1 levels. Our purpose was to analyze the dimensions of maxillary and mandibular dental arches.

Methods

22 adult IGHD (15 untreated and 7 previously partially treated with GH) and 33 controls were enrolled in a cross-sectional study using the Ortho Insight 3D and MeshMixer software,

Results

In untreated IGHD subjects all maxillary arch measures were smaller than controls, while among mandibular arches, only the mandibular canine width and the mandibular arch length were reduced. In partially GH treated subjects only the palate depth, the maxillary canine width, the maxillary and mandibular arch lengths remained smaller than controls.

Conclusions

IGHD reduces the growth of maxillary arch to a greater degree than the mandibular arch, suggesting different control of superior and inferior dental arches. GH treatment increases some of these measures.

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遗传性严重分离生长激素缺乏症的牙弓
目的牙弓的生长依赖于生长激素和胰岛素样生长因子1型(IGF1),但生长激素缺乏(GHD)对牙弓生长的影响尚不清楚,可能是由于大多数描述的GHD的获得性病因,通常与额外的垂体缺陷(甲状腺、促皮质和促性腺激素)以及相关替代疗法的不完善有关,这可能会影响牙弓的生长。为了避免这些局限性,我们利用了一组独特的研究对象,这些研究对象是由于生长激素释放激素受体基因的相同突变而孤立的生长激素缺乏症(IGHD),他们的血清生长激素非常低,循环IGF1水平低到无法检测。我们的目的是分析上颌和下颌牙弓的尺寸。方法采用Ortho Insight 3D和MeshMixer软件对22名成人IGHD患者(15名未治疗,7名曾部分接受GH治疗)和33名对照组进行横断面研究。结果未治疗的IGHD患者上颌弓的测量值均小于对照组,而在下颌弓中,只有下颌犬齿宽度和下颌弓长度减小。在部分GH治疗的受试者中,只有上颚深度、上颌犬齿宽度、上颌和下颌弓长度比对照组小。结论sigd对上颌弓生长的抑制作用大于对下颌骨弓生长的抑制作用,说明对上下牙弓的控制是不同的。生长激素治疗增加了这些措施中的一些。
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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
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