Antiviral roles of APOBEC proteins against HIV-1 and suppression by Vif

IF 2.5 4区医学 Q3 VIROLOGY Archives of Virology Pub Date : 2009-08-12 DOI:10.1007/s00705-009-0481-y

Bizhan Romani, Susan Engelbrecht, Richard H. Glashoff

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引用次数: 36

Abstract

Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like (APOBEC) proteins are members of a protein family sharing the common characteristic of cytidine deaminase activity. The antiviral activity of APOBEC3G and APOBEC3F has been studied more extensively than that of the other members of this family. The antiviral activity of APOBEC3B and APOBEC3DE has also been described. Studies of other APOBEC proteins have not revealed any antiviral activities against HIV-1; however, further investigation is required. In the absence of human immunodeficiency virus type 1 (HIV-1) virion infectivity factor (Vif), APOBEC3G and APOBEC3F are incorporated into HIV-1 virions and hypermutate the viral genomic DNA by their cytidine deaminase activity. HIV-1 Vif protein suppresses the antiviral role of APOBEC proteins by several mechanisms that lead to inhibition of incorporation of APOBEC3G/3F into HIV-1 virions. The detailed mechanisms involved in the suppression of APOBEC proteins by Vif are still being elucidated. Novel studies in which as yet undefined aspects of the suppression of APOBEC proteins are investigated could reveal important and potentially exploitable information for addressing HIV-1 infection in humans.

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APOBEC蛋白对HIV-1的抗病毒作用及Vif的抑制作用

载脂蛋白B mrna编辑酶催化多肽样(APOBEC)蛋白是具有胞苷脱氨酶活性的蛋白质家族的成员。与该家族的其他成员相比，APOBEC3G和APOBEC3F的抗病毒活性研究更为广泛。APOBEC3B和APOBEC3DE的抗病毒活性也有报道。其他APOBEC蛋白的研究未发现任何抗病毒活性。然而，还需要进一步的调查。在缺乏人类免疫缺陷病毒1型(HIV-1)病毒粒子感染因子(Vif)的情况下，APOBEC3G和APOBEC3F被整合到HIV-1病毒粒子中，并通过其胞苷脱氨酶活性使病毒基因组DNA发生超突变。HIV-1病毒体Vif蛋白通过多种机制抑制APOBEC3G/3F进入HIV-1病毒体的作用。Vif抑制APOBEC蛋白的具体机制仍在研究中。在新的研究中，对APOBEC蛋白抑制的尚未定义的方面进行了研究，可以揭示解决人类HIV-1感染的重要和潜在的可利用信息。

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来源期刊

Archives of Virology 医学-病毒学

CiteScore

5.10

自引率

7.40%

发文量

324

审稿时长

4.5 months

期刊介绍： Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.