The kinetics of lactate production and removal during whole-body exercise.

John F Moxnes, Øyvind Sandbakk
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引用次数: 1

Abstract

Background: Based on a literature review, the current study aimed to construct mathematical models of lactate production and removal in both muscles and blood during steady state and at varying intensities during whole-body exercise. In order to experimentally test the models in dynamic situations, a cross-country skier performed laboratory tests while treadmill roller skiing, from where work rate, aerobic power and blood lactate concentration were measured. A two-compartment simulation model for blood lactate production and removal was constructed.

Results: The simulated and experimental data differed less than 0.5 mmol/L both during steady state and varying sub-maximal intensities. However, the simulation model for lactate removal after high exercise intensities seems to require further examination.

Conclusions: Overall, the simulation models of lactate production and removal provide useful insight into the parameters that affect blood lactate response, and specifically how blood lactate concentration during practical training and testing in dynamical situations should be interpreted.

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全身运动过程中乳酸生成和清除的动力学。
背景:在文献综述的基础上,本研究旨在构建肌肉和血液在稳态和全身运动中不同强度下乳酸产生和去除的数学模型。为了在动态情况下对模型进行实验测试,一名越野滑雪运动员在跑步机滚轴滑雪时进行了实验室测试,测量了功率、有氧能力和血液乳酸浓度。建立了血液乳酸生成和去除的两室模拟模型。结果:模拟和实验数据在稳态和不同亚最大强度下的差异均小于0.5 mmol/L。然而,高强度运动后乳酸去除的模拟模型似乎需要进一步检查。结论:总的来说,乳酸产生和去除的模拟模型为影响血液乳酸反应的参数提供了有用的见解,特别是如何解释动态情况下实际训练和测试中的血液乳酸浓度。
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Theoretical Biology and Medical Modelling
Theoretical Biology and Medical Modelling MATHEMATICAL & COMPUTATIONAL BIOLOGY-
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6-12 weeks
期刊介绍: Theoretical Biology and Medical Modelling is an open access peer-reviewed journal adopting a broad definition of "biology" and focusing on theoretical ideas and models associated with developments in biology and medicine. Mathematicians, biologists and clinicians of various specialisms, philosophers and historians of science are all contributing to the emergence of novel concepts in an age of systems biology, bioinformatics and computer modelling. This is the field in which Theoretical Biology and Medical Modelling operates. We welcome submissions that are technically sound and offering either improved understanding in biology and medicine or progress in theory or method.
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