[Multimodal therapy of dyslipidemia].

Annett Stahn, Markolf Hanefeld
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Abstract

In the multifactorial process of atherogenesis not only increased LDL-cholesterol but also decreased HDL-cholesterol and raised triglycerides correlate closely to cardiovascular events. Multiple studies have demonstrated a high prevalence of dyslipidemia and the metabolic syndrome in Germany.Statins remain first-line therapy for the treatment of dyslipidemia. However, despite therapy a relevant cardiovascular risk remains. Therefore, it is important to also aim for an adequate treatment of hypertriglyceridemia and also to raise HDL-levels. Many combination therapies have been shown to be effective in treating dyslipidemia. Adding Omega-3-fatty acids, nicotinic acid/laropiprant or a fibrate to statin monotherapy provide additional beneficial lipid-modifying effects for combined dyslipidemia. In the future a recommendation for the treatment of mixed hyperlipoproteinemia with decreased HDL, raised triglycerides and LDL-cholesterol shall have to be added to our guidelines.

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[血脂异常的多模式治疗]。
在动脉粥样硬化的多因素过程中,ldl -胆固醇升高、hdl -胆固醇降低和甘油三酯升高不仅与心血管事件密切相关。多项研究表明,德国血脂异常和代谢综合征的患病率很高。他汀类药物仍然是治疗血脂异常的一线药物。然而,尽管治疗,相关的心血管风险仍然存在。因此,适当治疗高甘油三酯血症和提高高密度脂蛋白水平是很重要的。许多联合疗法已被证明对治疗血脂异常有效。在他汀类药物单药治疗中加入omega -3脂肪酸、烟酸/laropiprant或贝特可为合并型血脂异常提供额外有益的降脂效果。在未来,我们的指南中必须增加对混合性高脂蛋白血症伴HDL降低、甘油三酯和ldl -胆固醇升高的治疗建议。
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来源期刊
Clinical Research in Cardiology Supplements
Clinical Research in Cardiology Supplements Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
6.10
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0.00%
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Lipoprotein apheresis is an optimal therapeutic option to reduce increased Lp(a) levels. Is lipoprotein(a) a risk factor for ischemic stroke and venous thromboembolism? Lipoprotein(a) and mortality-a high risk relationship. Lipoprotein(a) and proprotein convertase subtilisin/kexin type 9 inhibitors. Lipoprotein(a)-an interdisciplinary challenge.
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