Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current Management.

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL Medeniyet medical journal Pub Date : 2022-06-23 DOI:10.4274/MMJ.galenos.2022.63139

Anam Yousaf, Sarina Sulong, Baharudin Abdullah, Norhafiza Mat Lazim

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引用次数: 4

Abstract

Salivary gland neoplasms (SGNs) are rare and heterogeneous tumors in the head and neck region. Although progress has been recently made in revealing the molecular landscape of salivary glands tumors, it is limited and appears to be the tip of the iceberg. Some genetic aberrations include chromosomal translocations, such as CRTC1/3-MAML2 in mucoepidermoid carcinoma, g MYB-NFIB gene fusions in adenoid cystic carcinoma, and PLAG1-HMGA2 gene changes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma. These chromosomal translocations provide fresh insights into the molecular etiology of diverse SGNs and aid in their classification and in approaching treatment. In future, these genetic variations may serve as critical tools for diagnosing salivary gland tumors and optimizing the management as well as prognosis of patients. This review presents the most recent advances in the molecular pathology of salivary gland cancers, with an emphasis on distinguishing molecular features that can be used for optimizing current patient management.

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唾液腺肿瘤遗传景观的异质性及其在当前治疗中的关键作用。

唾液腺肿瘤(sgn)是头颈部罕见的异质性肿瘤。虽然最近在揭示唾液腺肿瘤的分子景观方面取得了进展，但它是有限的，似乎只是冰山一角。一些遗传畸变包括染色体易位，如粘液表皮样癌中的CRTC1/3-MAML2，腺样囊性癌中的g MYB-NFIB基因融合，多形性腺瘤和癌外多形性腺瘤中的PLAG1-HMGA2基因改变。这些染色体易位为不同sgn的分子病因提供了新的见解，并有助于其分类和接近治疗。未来，这些遗传变异可能作为诊断唾液腺肿瘤和优化患者管理和预后的关键工具。本文综述了唾液腺癌分子病理学的最新进展，重点介绍了可用于优化当前患者管理的区分分子特征。

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来源期刊

Medeniyet medical journal Medicine-Medicine (all)

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

5 weeks

期刊介绍： The Medeniyet Medical Journal (Medeniyet Med J) is an open access, peer-reviewed, and scientific journal of Istanbul Medeniyet University Faculty of Medicine on various academic disciplines in medicine, which is published in English four times a year, in March, June, September, and December by a group of academics. Medeniyet Medical Journal is the continuation of Göztepe Medical Journal (ISSN: 1300-526X) which was started publishing in 1985. It changed the name as Medeniyet Medical Journal in 2015. Submission and publication are free of charge. No fees are asked from the authors for evaluation or publication process. All published articles are available online in the journal website (www.medeniyetmedicaljournal.org) without any fee. The journal publishes intradisciplinary or interdisciplinary clinical, experimental, and basic researches as well as original case reports, reviews, invited reviews, or letters to the editor, Being published since 1985, the Medeniyet Med J recognizes that the best science should lead to better lives based on the fact that the medicine should serve to the needs of society, and knowledge should transform society. The journal aims to address current issues at both national and international levels, start debates, and exert an influence on decision-makers all over the world by integrating science in everyday life. Medeniyet Med J is committed to serve the public and influence people’s lives in a positive way by making science widely accessible. Believing that the only goal is improving lives, and research has an impact on people’s lives, we select the best research papers in line with this goal.