[A convenient approach to the synthesis of the phosphoramidite non-nucleotide monomers for the preparation of functionalized oligonucleotide derivatives].

Bioorganicheskaia khimiia Pub Date : 2012-11-01
M S Kopriushkin, D V Pyshnyĭ
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Abstract

A simple approach to the synthesis of phosphoramidite synthons for non-nucleotide inserts using 4-(2-(4,4'-dimethoxytrityloxy)ethyl)morpholine-2,3-dione as a key precursor is suggested. Using the method developed various inserts have been introduced into oligonucleotides to obtain intercalator-containing (acridine) as well as branched oligonucleotides.

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[一种制备功能化寡核苷酸衍生物的酰胺磷非核苷酸单体的便捷方法]。
提出了一种以4-(2-(4,4'-二甲氧基三羧基)乙基)morpholine-2,3-dione为关键前体合成非核苷酸插入物的磷酸酰胺合成物的简单方法。利用该方法,将各种插入物引入到寡核苷酸中,得到含插入物(吖啶)和支链寡核苷酸。
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